지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 11 - 17 (7page)
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초록· 키워드
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Appropriate control of diet and water intake is important for maintaining normal blood pressure, fluid and electrolyte homeostasis in the body. It is relatively under stood that the amount of sodium and potassium intake directly affects blood pressure and regulates ion transporters; Na and K channel functions in the kidney.
However, little is known about whether diet and water intake regulates Aquaporin (AQP) function. AQPs, a family of aquaporin proteins with different types being expressed in different tissues, are important for water absorption by the cell. Water reabsorption is a passive process driven by osmotic gradient and water permeability is critical for this process. In most of the nephron, however, water reabsorption is unregulated and coupled to solute reabsorption, such as AQP1 mediated water absorption in the proximal tubule. AQP2 is the only water channel founded so far that can be regulated by hormones in the kidney. AQP2 expressed in the apical membrane of the principal cells in the collecting tubule can be regulated by vaso pressin (antidiuretic hormone) controlling the final volume of urine excretion.
When vasopressin binds to its receptor on the collecting duct cells, it stimulates the translocation of AQP2 to the membrane, leading to increased water absorption via this AQP2 water channel. However, some studies also indicated that the AQP2 is also been regulated by vasopressin independent mechanism. This review is focused on the regulation of AQP2 by diet and the amount of water intake on salt and water homeostasis.
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참고문헌 (35)
참고문헌 신청
Preston GM / 1992 / Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein / Science 256:385~387
Kortenoeven ML / 2014 / Renal aquaporins and water balance disorders / Biochim Biophys Acta 1840:1533~1549
Nielsen S / 2002 / Aquaporins in the kidney : from molecules to medicine / Physiol Rev 82:205~244
Matsuzaki T / 2016 / The distribution and function of aquaporins in the kidney: resolved and unresolved questions / Anat Sci Int
Stanton BA / 2004 / Physiology / Elsevier Mosby :643~658
Kortenoeven ML / 2014 / Renal aquaporins and water balance disorders / Biochim Biophys Acta 1840:1533~1549
Nielsen S / 2002 / Aquaporins in the kidney : from molecules to medicine / Physiol Rev 82:205~244
Matsuzaki T / 2016 / The distribution and function of aquaporins in the kidney: resolved and unresolved questions / Anat Sci Int
Stanton BA / 2004 / Physiology / Elsevier Mosby :643~658
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