지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 47 - 52 (6page)
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초록· 키워드
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Background: Aquaporin-11 (AQP11) is a novel member of the aquaporin family.
Disruption of the murine Aqp11 gene causes severe proximal tubular injury andrenal failure. The rs2276415 (G4A) single-nucleotide polymorphism in the humanAQP11 gene results in glycine to serine substitution in a functionally importantdomain. In this study, the role of the genetic predispositions of AQP11 rs2276415(G4A) on renal allograft outcomes was evaluated.
Methods: A total of 198 pairs of donors and recipients were enrolled in this study.
Long-term graft survival was traced and clinical parameters that could haveinfluenced graft outcome were collected through the electronic medical recordsystem.
Results: The genotype distribution and allele frequency of rs2276415 polymorphismwere not different between donors and recipients. Despite similar allelefrequencies between donors and recipients, the minor allele rs2276415 (GAþAA)of AQP11 from the donors, but not from the recipients, had a harmful effect on thegraft survival compared with the wild-type donor (GG; P¼0.029). This associationwas significant after adjusting for several risk factors including age, sex, humanleukocyte antigen mismatch, donor type, hypertension, and diabetes mellitus(P¼0.032).
Conclusion: A donor-derived, not recipient-derived, genetic AQP11 polymorphismhas different effects on graft outcome. Thus, the genetic influence from donorsshould be carefully considered for proper management of allografts after kidneytransplantation.
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참고문헌 (20)
참고문헌 신청
Walz T / 2009 / The AQP structure and functional implications / Handb Exp Pharmacol :31~56
Morishita Y / 2005 / Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule / Mol Cell Biol 25:7770~7779
Choma DP / 2011 / A single nucleotide polymorphism in the Aqp11 gene is associated with an increased risk for chronic kidney disease in patients with diabetes / American Society of Nephrology
Levey AS / 1999 / A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group / Ann Intern Med 130:461~470
이승헌 / 2014 / Cyst growth, polycystins, and primary cilia in autosomal dominant polycystic kidney disease / Kidney Research and Clinical Practice 33(2):73~78
Morishita Y / 2005 / Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule / Mol Cell Biol 25:7770~7779
Choma DP / 2011 / A single nucleotide polymorphism in the Aqp11 gene is associated with an increased risk for chronic kidney disease in patients with diabetes / American Society of Nephrology
Levey AS / 1999 / A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group / Ann Intern Med 130:461~470
이승헌 / 2014 / Cyst growth, polycystins, and primary cilia in autosomal dominant polycystic kidney disease / Kidney Research and Clinical Practice 33(2):73~78
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