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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제50권 제2호
- 발행연도
- 2016.1
- 수록면
- 122 - 128 (7page)
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초록· 키워드
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Background: Aquaporins are water channel proteins that play a major role in the movement of water in various human tissues. Recently, it has been found that aquaporins have influence in the carcinogenesis of human malignancies. We analyzed the prognostic impact of aquaporin 5 (AQP5) in non-small lung cancer (NSCLC). Methods: Seventy-six cases of NSCLC were studied, including 44 cases of adenocarcinoma (ADC) and 32 cases of squamous cell carcinoma (SQCC). Tissue microarray was constructed and immunohistochemical staining for AQP5 was performed. Results: AQP5 was positive in 59.2% of the total enrolled NSCLCs (63.7% in ADC and 53.1% in SQCC). The difference in expression of AQP5 according to the histologic grade of the tumor was significant (p < .047), but not in a serial order. When ADC and SQCC were separately evaluated, no significant difference was observed according to the histologic grade of the tumor (p = .076 in ADC and p = .631 in SQCC). No difference was observed between AQP5 expression and other demographic data and tumor characteristics. Disease-free survival (DFS) was higher in AQP5 negative cases than positive cases in ADC (p = .047), but no significance was found in SQCC (p = .068). We were unable to find a significance between AQP5 overexpression and overall survival in either ADC (p = .210) or SQCC (p = .533). Conclusions: AQP5 expression is associated with DFS in ADC of the lung and tumor grade of NSCLC. The present study suggests that AQP5 can be a prognostic factor of NSCLC.
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참고문헌 (17)
참고문헌 신청
Travis WD / 2015 / WHO classification of tumours of the lung, pleura, thymus and heart / IARC Press :26~52
King LS / 1996 / Pathophysiology of the aquaporin water channels / Annu Rev Physiol 58:619~648
Verkman AS / 1996 / Water transport across mammalian cell membranes / Am J Physiol 1(1 Pt 1):C12~C30
Vogelstein B / 2004 / Cancer genes and the pathways they control / Nat Med 10:789~799
Saadoun S / 2002 / Increased aquaporin 1 water channel expression in human brain tumours / Br J Cancer 87:621~623
King LS / 1996 / Pathophysiology of the aquaporin water channels / Annu Rev Physiol 58:619~648
Verkman AS / 1996 / Water transport across mammalian cell membranes / Am J Physiol 1(1 Pt 1):C12~C30
Vogelstein B / 2004 / Cancer genes and the pathways they control / Nat Med 10:789~799
Saadoun S / 2002 / Increased aquaporin 1 water channel expression in human brain tumours / Br J Cancer 87:621~623
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Mannosylerythritol lipids ameliorate ultraviolet A-induced aquaporin-3 downregulation by suppressing c-Jun N-terminal kinase phosphorylation in cultured human keratinocytes
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Programmed death-ligand 1 expression and tumor-infiltrating lymphocytes in non-small cell lung cancer: association with clinicopathologic parameters
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