지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제50권 제4호
- 발행연도
- 2016.1
- 수록면
- 251 - 257 (7page)
이용수
초록· 키워드
오류제보하기
Background: Aquaporin 1 (AQP1) overexpression has been shown to be associated with uncontrolled cell replication, invasion, migration, and tumor metastasis. We aimed to evaluate AQP1 expression in lung adenocarcinomas and to examine its association with clinicopathological features and prognostic significance. We also investigated the association between AQP1 overexpression and epithelial-mesenchymal transition (EMT) markers. Methods: We examined AQP1 expression in 505 cases of surgically resected lung adenocarcinomas acquired at the Seoul National University Bundang Hospital from 2003 to 2012. Expression of AQP1 and EMT-related markers, including Ecadherin and vimentin, were analyzed by immunohistochemistry and tissue microarray. Results: AQP1 overexpression was associated with several aggressive pathological parameters, including venous invasion, lymphatic invasion, and tumor recurrence. AQP1 overexpression tended to be associated with higher histological grade, advanced pathological stage, and anaplastic lymphoma kinase (ALK) translocation; however, these differences were not statistically significant. In addition, AQP1 overexpression positively correlated with loss of E-cadherin expression and acquired expression of vimentin. Lung adenocarcinoma patients with AQP1 overexpression showed shorter progression-free survival (PFS, 46.1 months vs. 56.2 months) compared to patients without AQP1 overexpression. Multivariate analysis confirmed that AQP1 overexpression was significantly associated with shorter PFS (hazard ratio, 1.429; 95% confidence interval, 1.033 to 1.977; p = .031). Conclusions: AQP1 overexpression was thereby concluded to be an independent factor of poor prognosis associated with shorter PFS in lung adenocarcinoma. These results suggested that AQP1 overexpression might be considered as a prognostic biomarker of lung adenocarcinoma.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Kim JE / 2013 / High expression of Sonic hedgehog signaling proteins is related to the favorable outcome, EGFR mutation, and lepidic predominant subtype in primary lung adenocarcinoma / Ann Surg Oncol 20(Suppl 3):S570~S576
Seo AN / 2014 / Clinicopathologic and prognostic significance of c-MYC copy number gain in lung adenocarcinomas / Br J Cancer 110:2688~2699
Pao W / 2011 / New driver mutations in non-small-cell lung cancer / Lancet Oncol 12:175~180
Cuddapah VA / 2011 / Ion channels and transporters [corrected]in cancer. 2. Ion channels and the control of cancer cell migration / Am J Physiol Cell Physiol 301:C541~C549
Verkman AS / 2005 / More than just water channels: unexpected cellular roles of aquaporins / J Cell Sci 118(Pt 15):3225~3232
Seo AN / 2014 / Clinicopathologic and prognostic significance of c-MYC copy number gain in lung adenocarcinomas / Br J Cancer 110:2688~2699
Pao W / 2011 / New driver mutations in non-small-cell lung cancer / Lancet Oncol 12:175~180
Cuddapah VA / 2011 / Ion channels and transporters [corrected]in cancer. 2. Ion channels and the control of cancer cell migration / Am J Physiol Cell Physiol 301:C541~C549
Verkman AS / 2005 / More than just water channels: unexpected cellular roles of aquaporins / J Cell Sci 118(Pt 15):3225~3232
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