지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 211 - 217 (7page)
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초록· 키워드
오류제보하기
Molecular mimicry is the most common mechanism that breaches self-tolerance. We previously identifiedautoantibodies to aquaporin-5 (AQP5) in the sera of patients with Sjogren’s syndrome and found that the aquaporinof Prevotella melaninogenica (PmAqp), an oral commensal, is highly homologous to human AQP5. This study aimedto test whether PmAqp can induce anti-AQP5 autoantibodies via molecular mimicry. From the amino acid sequenceof PmAqp, an immunizing peptide; i.e., PmE-L, was designed, which contained both the B cell epitope “E” and T cellepitope. C57BL/6 and BALB/c mice were subcutaneously immunized with linear or cyclic forms of PmE-L emulsifiedin incomplete Freund’s adjuvant. The concentrations of the antibodies in sera were measured using enzymelinkedimmunosorbent assays. Both linear and cyclic PmE-L induced high levels of antibodies against not only theimmunized peptides but also autoantibodies against AQP5E and antibodies against PmE, a Pm homolog of AQP5E. In C57BL/6 mice; however, the cyclic form of PmE-L was more efficient than the linear form in inducing autoantibodiesagainst AQP5E that contained a cyclic epitope. The levels of anti-PmE antibodies and anti-AQP5E autoantibodiesshowed a strong positive correlation (r = 0.95, p < 0.0005), suggesting molecular mimicry. Collectively, the miceproduced anti-AQP5E autoantibodies in response to a PmAqp-derived peptide. This model proved to be useful forstudying the mechanisms of autoantibody production by molecular mimicry.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Christopher C. Goodnow / 2005 / Cellular and genetic mechanisms of self tolerance and autoimmunity / Nature 435(7042):590~597
U. Christen / 2019 / Pathogen infection and autoimmune disease / Clinical & Experimental Immunology 195(1):10~14
A. Sinha / 1990 / Autoimmune diseases: the failure of self tolerance / Science 248(4961):1380~1388
Matthew F. Cusick / 2012 / Molecular Mimicry as a Mechanism of Autoimmune Disease / Clinical Reviews in Allergy & Immunology 42(1):102~111
E. Ben-Chetrit / 1993 / Anti-SSA/Ro and anti-SSB/La antibodies in serum and saliva of patients with Sjogren's syndrome / Clinical Rheumatology 12(4):471~474
U. Christen / 2019 / Pathogen infection and autoimmune disease / Clinical & Experimental Immunology 195(1):10~14
A. Sinha / 1990 / Autoimmune diseases: the failure of self tolerance / Science 248(4961):1380~1388
Matthew F. Cusick / 2012 / Molecular Mimicry as a Mechanism of Autoimmune Disease / Clinical Reviews in Allergy & Immunology 42(1):102~111
E. Ben-Chetrit / 1993 / Anti-SSA/Ro and anti-SSB/La antibodies in serum and saliva of patients with Sjogren's syndrome / Clinical Rheumatology 12(4):471~474
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