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- 2015.1
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The kidney collecting duct is an important renal tubular segment for the regulation of body water and salt homeostasis. Water reabsorption in the collecting duct cells is regulated by arginine vasopressin (AVP) via the vasopressin V2-receptor (V2R). AVP increases the osmotic water permeability of the collecting duct cells through aquaporin-2 (AQP2) and aquaporin-3 (AQP3). AVP induces the apical targeting of AQP2 and transcription of AQP2 gene in the kidney collecting duct principal cells. The signaling transduction pathways resulting in the AQP2 trafficking to the apical plasma membrane of the collecting duct principal cells, include AQP2 phosphorylation, RhoA phosphorylation, actin depolymerization and calcium mobilization, and the changes of AQP2 protein abundance in water balance disorders have been extensively studied. These studies elucidate the underlying cellular and molecular mechanisms of body water homeostasis and provide the basis for the treatment of body water balance disorders.
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참고문헌 (43)
참고문헌 신청
Knepper MA / 2015 / Molecular physiology of water balance / N Engl J Med 372:1349~1358
Nielsen S / 2002 / Aquaporins in the kidney: from molecules to medicine / Physiol Rev 82:205~244
권태환 / 2013 / Regulation of aquaporin-2 in the kidney: A molecular mechanism of body-water homeostasis / Kidney Research and Clinical Practice 32(3):96~102
Knepper MA / 2012 / Systems biology in physiology: the vasopressin signaling network in kidney / Am J Physiol Cell Physiol 303:C1115~C1124
Kwon TH / 2009 / Aquaporins in the kidney / Handb Exp Pharmacol :95~132
Nielsen S / 2002 / Aquaporins in the kidney: from molecules to medicine / Physiol Rev 82:205~244
권태환 / 2013 / Regulation of aquaporin-2 in the kidney: A molecular mechanism of body-water homeostasis / Kidney Research and Clinical Practice 32(3):96~102
Knepper MA / 2012 / Systems biology in physiology: the vasopressin signaling network in kidney / Am J Physiol Cell Physiol 303:C1115~C1124
Kwon TH / 2009 / Aquaporins in the kidney / Handb Exp Pharmacol :95~132
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Prognostic Significance of Aquaporin 5 Expression in Non-small Cell Lung Cancer
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Decreased Aquaporin 4 and 6 mRNAs in Patients With Chronic Otitis Media With Otorrhea
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Detection of Autoantibodies against Aquaporin-1 in the Sera of Patients with Primary Sjögren’s Syndrome
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Aging changes in renal proximal tubule
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Cinnamaldehyde modulate dry mouth syndrome via AQP 5 signaling pathway in rat
한국실험동물학회 학술발표대회 논문집
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Genetic predisposition of donors affects the allograft outcome in kidney transplantation: Single-nucleotide polymorphism of aquaporin-11
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Mannosylerythritol lipids ameliorate ultraviolet A-induced aquaporin-3 downregulation by suppressing c-Jun N-terminal kinase phosphorylation in cultured human keratinocytes
The Korean Journal of Physiology & Pharmacology
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사염화탄소가 고혈압흰쥐 신장의 aquaporin과 superoxide dismutase 발현에 미치는 영향
해부·생물인류학
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Induction of anti-aquaporin 5 autoantibodies by molecular mimicry in mice
International Journal of Oral Biology
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Study on the Changes in Distributions and Expressions of Aquaporin5 (AQP5) in Salivary Glands of Mice After Alcohol Ingestion
International Journal of Oral Biology
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Expression of Aquaporin 1 in Bladder Uroepithelial Cell Carcinoma and its Relevance to Recurrence
Asian Pacific journal of cancer prevention : APJCP
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The Anti-Inflammatory Effect of Arginine-Vasopressin on Lipopolysaccharide-Induced IκBα/Nuclear Factor-κB Cascade
Acute and Critical Care
2015 .01
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A new water channel aquaporin-11: extension to renal transplantation
Kidney Research and Clinical Practice
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