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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1,012 - 1,017 (6page)
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초록· 키워드
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Purpose: Endothelial progenitor cells (EPCs) play a key role in tissue repair and regeneration. Previous studies have shown that infusion of human umbilical cord blood-derived endothelial colony-forming cells improves outcomes in mice subjected to experimentaltraumatic brain injury (TBI). However, the efficiency of cell transplantation is not satisfactory. Oxidative stress plays a significant role in the survival of transplanted cells following ischemic reperfusion injury. This observational clinical study investigatedthe correlation between the number of circulating EPCs and plasma levels of superoxide dismutase (SOD) and malonyldialdehyde(MDA).
Materials and Methods: Peripheral blood samples were collected from 20 patients with mild TBI at day-1, day-2, day-3, day-4, and day-7 post TBI. The number of circulating EPCs and the plasma levels of SOD and MDA were measured.
Results: The average of circulating EPCs in TBI patients decreased initially, but increased thereafter, compared with healthy controls.
Plasma levels of SOD in TBI patients were significantly lower than those in healthy controls at day-4 post-TBI. MDA levels showed no difference between the two groups. Furthermore, when assessed on day-7 post-TBI, the circulating EPC number were correlated with the plasma levels of SOD and MDA.
Conclusion: These results suggest that the number of circulating EPCs is weakly to moderately correlated with plasma levels of SOD and MDA at day-7 post-TBI, which may offer a novel antioxidant strategy for EPCs transplantation after TBI.
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참고문헌 (24)
참고문헌 신청
Abdul-Muneer PM / 2013 / Induction of oxidative and nitrosative damage leads to cerebrovascular inflammation in an animal model of mild traumatic brain injury induced by pri
Abdul-Muneer PM / 2015 / Interactions of oxidative stress and neurovascular inflammation in the pathogenesis of traumatic brain injury / Mol Neurobiol 51 : 966 ~ 979
Asahara T / 1997 / Isolation of putative progenitor endothelial cells for angiogenesis / Science 275 : 964 ~ 967
Bayir H / 2002 / Assessment of antioxidant reserves and oxidative stress in cerebrospinal fluid after severe traumatic brain injury in infants and children / Pediatr Res 51
Briasoulis A / 2011 / The role of endothelial progenitor cells in vascular repair after arterial injury and atherosclerotic plaque development / Cardiovasc Ther 29 : 125 ~ 13
Abdul-Muneer PM / 2015 / Interactions of oxidative stress and neurovascular inflammation in the pathogenesis of traumatic brain injury / Mol Neurobiol 51 : 966 ~ 979
Asahara T / 1997 / Isolation of putative progenitor endothelial cells for angiogenesis / Science 275 : 964 ~ 967
Bayir H / 2002 / Assessment of antioxidant reserves and oxidative stress in cerebrospinal fluid after severe traumatic brain injury in infants and children / Pediatr Res 51
Briasoulis A / 2011 / The role of endothelial progenitor cells in vascular repair after arterial injury and atherosclerotic plaque development / Cardiovasc Ther 29 : 125 ~ 13
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