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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 502 - 513 (12page)
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초록· 키워드
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Objective To evaluate the effects of electric cortical stimulation (ECS) and transcranial direct current stimulation (tDCS) on motor and cognitive function recovery and brain plasticity in focal traumatic brain injury (TBI) of rats model. Methods Forty rats were pre-trained to perform a single pellet reaching task (SPRT), rotarod test (RRT), and Y-maze test for 14 days, then a focal TBI was induced by a weight drop model on the motor cortex. All rats were randomly assigned to one of the three groups: anodal ECS (50 Hz and 194 μs) (ECS group), tDCS (0.1 mA, 50 Hz and 200 μs) (tDCS group), and no stimulation as a control group. Four-week stimulation, including rehabilitation, was started 3 days after the operation. SPRT, RRT, and Y-maze were measured from day 1 to day 28 after the TBI was induced. Histopathological and immunohistochemistry staining evaluations were performed at 4 weeks. Results SPRT was improved from day 7 to day 26 in ECS, and from day 8 to day 26 in tDCS compared to the control group (p<0.05). SPRT of ECS group was significantly improved on days 3, 8, 9, and 17 compared to the tDCS group. Y-maze was improved from day 8 to day 16 in ECS, and on days 6, 12, and 16 in the tDCS group compared to the control group (p<0.05). Y-maze of the ECS group was significantly improved on day 9 to day 15 compared to the tDCS group. The c-Fos protein expression was better in the ECS group and the tDCS group compared to the control group. Conclusion Electric stimulation in rats modified with a focal TBI is effective for motor recovery and brain plasticity. ECS induced faster behavioral and cognitive improvements compared to tDCS during the recovery period of rats with a focal TBI.
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등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Harvey RL / 2007 / Cortical brain stimulation: a potential therapeutic agent for upper limb motor recovery following stroke / Top Stroke Rehabil 14:54~67
Minhas AS / 2009 / Magnetic flux density measurement with balanced steady state free precession pulse sequence for MREIT: a simulation study / Conf Proc IEEE Eng Med Biol Soc 2009:2276~2278
Martin PI / 2004 / Transcranial magnetic stimulation as a complementary treatment for aphasia / Semin Speech Lang 25:181~191
Kim HI / 2008 / Unipolar and continuous cortical stimulation to enhance motor and language deficit in patients with chronic stroke: report of 2 cases / Surg Neurol 69:77~80
Brown JA / 2006 / Motor cortex stimulation for the enhancement of recovery from stroke: a prospective, multicenter safety study / Neurosurgery 58:464~473
Minhas AS / 2009 / Magnetic flux density measurement with balanced steady state free precession pulse sequence for MREIT: a simulation study / Conf Proc IEEE Eng Med Biol Soc 2009:2276~2278
Martin PI / 2004 / Transcranial magnetic stimulation as a complementary treatment for aphasia / Semin Speech Lang 25:181~191
Kim HI / 2008 / Unipolar and continuous cortical stimulation to enhance motor and language deficit in patients with chronic stroke: report of 2 cases / Surg Neurol 69:77~80
Brown JA / 2006 / Motor cortex stimulation for the enhancement of recovery from stroke: a prospective, multicenter safety study / Neurosurgery 58:464~473
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