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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 34 - 38 (5page)
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Background: The associations of vitamin D deficiency with various clinical conditions highlighted the importance of vitamin D testing. Currently, clinicians measure only the total 25-hydroxyvitamin D [25(OH)D] concentration, regardless of its bioavailability. We aimed to determine the effect of vitamin D-binding protein (VDBP) on 25(OH)D bioavailability.
Methods: Serum samples were collected from 60 healthy controls, 50 pregnant women, and 50 patients in intensive care units (ICUs). Total 25(OH)D was quantified by liquid chromatography with tandem mass spectrometry, and VDBP levels were determined by using an ELISA kit (R&D Systems, USA). The bioavailable 25(OH)D levels were calculated by using total 25(OH)D, VDBP, and albumin concentrations.
Results: In comparison with healthy controls, the total 25(OH)D concentration was significantly lower in ICU patients (median, 11.65 vs 18.25 ng/mL; P<0.00001), but no significant difference was noted between pregnant women (18.25 ng/mL) and healthy controls. The VDBP level was significantly lower in ICU patients (95.58 vs 167.18 μg/mL, P=0.0002) and higher in pregnant women (225.01 vs 167.18 μg/mL, P=0.008) compared with healthy controls. Nonetheless, the calculated bioavailable 25(OH)D levels of ICU patients and pregnant women were significantly lower than those of healthy controls (1.97 and 1.93 ng/mL vs 2.56 ng/mL; P=0.0073 and 0.0027).
Conclusions: A single marker of the total 25(OH)D level is not sufficient to accurately evaluate vitamin D status, especially in pregnant women. In cases where VDBP concentrations may be altered, VDBP measurements and bioavailable 25(OH)D calculations may help to determine vitamin D status accurately.
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참고문헌 (25)
참고문헌 신청
Arnaud J / 1993 / Affinity differences for vitamin D metabolites associated with the genetic isoforms of the human serum carrier protein (DBP) / Hum Genet 92 : 183 ~ 188
Bhan I / 2012 / Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patients / Kidney Int 82 : 84 ~ 89
Bhan I / 2014 / Vitamin D binding protein and bone health / Int J Endocrinol 2014 : 561214 ~
Bikle DD / 1984 / Free 1,25-dihydroxy vitamin D levels in serum from normal subject, pregnant subjects, and subjects with liver disease / J Clin Invest 74 : 1966 ~ 1971
Bikle DD / 1985 / Serum protein binding of 1,25-dihydroxyvitamin D: a reevaluation by direct measurement of free metabolite levels / J Clin Endocrinol Metab 61 : 969 ~ 975
Bhan I / 2012 / Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patients / Kidney Int 82 : 84 ~ 89
Bhan I / 2014 / Vitamin D binding protein and bone health / Int J Endocrinol 2014 : 561214 ~
Bikle DD / 1984 / Free 1,25-dihydroxy vitamin D levels in serum from normal subject, pregnant subjects, and subjects with liver disease / J Clin Invest 74 : 1966 ~ 1971
Bikle DD / 1985 / Serum protein binding of 1,25-dihydroxyvitamin D: a reevaluation by direct measurement of free metabolite levels / J Clin Endocrinol Metab 61 : 969 ~ 975
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