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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제22권 제4호
- 발행연도
- 2017.1
- 수록면
- 247 - 252 (6page)
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Purpose: Vitamin D deficiency is reported to be more common in type 1 diabetes patients and might be associated with the increased urinary loss of vitamin D binding protein (VDBP) consequent to impaired 25-hydroxyvitamin D (25(OH)D) circulation. We aimed to evaluate the possible increased urinary loss of VDBP, a correlation between VDBP and circulating 25(OH)D level, and risk factors influencing low vitamin D level in pediatric type 1 diabetes patients without microalbuminuria.
Methods: This is a cross-sectional study of subjects who visited Seoul National University Children’s Hospital between January and March 2013. Forty-two type 1 diabetes patients and 29 healthy controls were included. Biochemical parameters including serum and urine VDBP concentrations were analyzed.
Results: There was no significant difference in the frequency of vitamin D deficiency or serum 25(OH)D level between the 2 groups. The serum and urine VDBP concentrations did not show any difference between the 2 groups. Serum 25(OH)D level did not correlate with serum or urine VDBP. Multivariate regression analysis revealed that daylight outdoor hours (β=2.948, P=0.003) and vitamin D intake (β=2.865, P=0.003) affected the 25(OH)D level; the presence of type 1 diabetes or urinary VDBP excretion was not significant.
Conclusion: In pediatric type 1 diabetes patients, urinary VDBP excretion did not contribute to low serum 25(OH)D level in the setting of normoalbuminuria. The factors associated with 25(OH)D level during winter periods were daylight outdoor hours and vitamin D intake. Further studies including both micro- and macroalbuminuria patients with type 1 diabetes are warranted.
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참고문헌 (30)
참고문헌 신청
Winters SJ / 2009 / Influence of obesity on vitamin D-binding protein and 25-hydroxy vitamin D levels in African American and white women / Metabolism 58:438~442
Carpenter TO / 2013 / Vitamin D binding protein is a key determinant of 25-hydroxyvitamin D levels in infants and toddlers / J Bone Miner Res 28:213~221
Speeckaert M / 2006 / Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism / Clin Chim Acta 372:33~42
Hamed EA / 2011 / Parathormone--25(OH)-vitamin D axis and bone status in children and adolescents with type 1 diabetes mellitus / Pediatr Diabetes 12:536~546
Chakhtoura M / 2013 / The role of vitamin d deficiency in the incidence, progression, and complications of type 1 diabetes mellitus / Int J Endocrinol 2013:148673
Carpenter TO / 2013 / Vitamin D binding protein is a key determinant of 25-hydroxyvitamin D levels in infants and toddlers / J Bone Miner Res 28:213~221
Speeckaert M / 2006 / Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism / Clin Chim Acta 372:33~42
Hamed EA / 2011 / Parathormone--25(OH)-vitamin D axis and bone status in children and adolescents with type 1 diabetes mellitus / Pediatr Diabetes 12:536~546
Chakhtoura M / 2013 / The role of vitamin d deficiency in the incidence, progression, and complications of type 1 diabetes mellitus / Int J Endocrinol 2013:148673
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