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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 89 - 94 (6page)
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초록· 키워드
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Aanaplastic lymphoma kinase (ALK)-positive diffuse large B-cell lymphoma (DLBCL) is an unusual
disease entity first reported in 1997 as DLBCL with expression of full-length ALK protein. The World
Health Organization classification enlists the disease as a rare variant of DLBCL. Herein we describe
two cases of ALK-positive DLBCL with cytomorphologic and molecular characteristics for the first
time in Korea. The patients were 35-yr-old and 24-yr-old male patients. Immunohistochemical studies
on the lymph nodes revealed large sized neoplastic cells with plasmablastic differentiation, which
were negative for CD30 and positive for ALK with the characteristic granular staining in the cytoplasmic
region. Extensive involvement of bone marrow was observed in both cases showing large, extremely
atypical cells. Fluorescence in situ hybridization and molecular studies on the bone marrow aspirate
specimens led to the detection of a clathrin (CLTC)/ALK rearrangement. Despite aggressive
chemotherapy, the patients died 15 and 17 months after the diagnosis, indicating poor prognosis
of the disease entity. This is the first report demonstrating the cytomorphologic findings of ALK-positive
DLBCL cells on bone marrow aspirates. (Korean J Lab Med 2008;28:89-94)
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Adam P / 2003 / A case of a diffuse large B-cell lymphoma of plasmablastic type associated with the t(2;5)(p23;q35) chromosome translocation / Am J Surg Pathol 27 : 1473 ~ 14
Bridge JA / 2001 / Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor / Am J Pathol 159 : 411 ~ 415
Bubala H / 2006 / ALK-positive diffuse large B-cell lymphoma / Pediatr Blood Cancer 46 : 649 ~ 653
Chikatsu N / 2003 / ALK+, CD30-, CD20- large B-cell lymphoma containing anaplastic lymphoma kinase (ALK) fused to clathrin heavy chain gene (CLTC) / Mod Pathol 16 : 828 ~ 832
De Paepe P / 2003 / ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma / Blood 102 : 2638 ~ 2641
Bridge JA / 2001 / Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor / Am J Pathol 159 : 411 ~ 415
Bubala H / 2006 / ALK-positive diffuse large B-cell lymphoma / Pediatr Blood Cancer 46 : 649 ~ 653
Chikatsu N / 2003 / ALK+, CD30-, CD20- large B-cell lymphoma containing anaplastic lymphoma kinase (ALK) fused to clathrin heavy chain gene (CLTC) / Mod Pathol 16 : 828 ~ 832
De Paepe P / 2003 / ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma / Blood 102 : 2638 ~ 2641
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Analysis of Histologic Features Suspecting Anaplastic Lymphoma Kinase (ALK)-Expressing Pulmonary Adenocarcinoma
Journal of Pathology and Translational Medicine
2015 .01
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Alterations in PD-L1 Expression Associated with Acquisition of Resistance to ALK Inhibitors in ALK-Rearranged Lung Cancer
Cancer Research and Treatment
2019 .01
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Guideline Recommendations for Testing of ALK Gene Rearrangement in Lung Cancer: A Proposal of the Korean Cardiopulmonary Pathology Study Group
Journal of Pathology and Translational Medicine
2014 .01
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ALK-Positive Renal Cell Carcinoma in a Large Series of Consecutively Resected Korean Renal Cell Carcinoma Patients
Journal of Pathology and Translational Medicine
2013 .01
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큰세포역형성림프종의 ALK 표현을 포함한 임상병리학상 상관관계
Journal of Pathology and Translational Medicine
2013 .01
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Characteristics of Renal Cell Carcinoma Harboring TPM3-ALK Fusion
Yonsei Medical Journal
2020 .01
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ALK Protein Expression Is Related to Neuroblastoma Aggressiveness But Is Not Independent Prognostic Factor
Cancer Research and Treatment
2018 .01
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Bilateral Ovarian Metastases from ALK Rearranged Non-Small Cell Lung Cancer
Tuberculosis and Respiratory Diseases
2014 .01
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새로운 합성 ALK5 저해제인 IN-1130의 생체조직 내 분포 및 대사
환경독성보건학회 심포지엄 및 학술대회
2006 .11
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Clinicopathological Study of 18 Cases of Inflammatory Myofibroblastic Tumors with Reference to ALK-1 Expression: 5-Year Experience in a Tertiary Care Center
Journal of Pathology and Translational Medicine
2017 .01
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Novel 2,4-dianilino-5-fluoropyrimidine derivatives possessing ALK inhibitory activities
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2014 .01
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SEC31A-ALKFusion Gene in Lung Adenocarcinoma
Cancer Research and Treatment
2016 .01
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Primary Central Nervous System ALK Positive Anaplastic Large Cell Lymphoma with Predominantly Leptomeningeal Involvement in an Adult
Yonsei Medical Journal
2013 .01
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Retrospective Study of ALK Rearrangement and Clinicopathological Implications in Completely Resected Non-small Cell Lung Cancer Patients in Northern Thailand: Role of Screening with D5F3 Antibodies
Asian Pacific journal of cancer prevention : APJCP
2014 .01
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Determination of metabolic enzymes involved in biotransformation of IN-1130, an ALK5 inhibitor
환경독성보건학회 심포지엄 및 학술대회
2007 .05
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EGFR 돌연변이와 ALK 재배열 공존하는 폐선암 환자 1예
대한내과학회지
2016 .01
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ALK 음성 원발성 위 역형성 큰세포 림프종 1예
대한내과학회지
2012 .01
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위 원발성 ALK 양성 역형성대세포림프종 1예
대한내과학회지
2012 .01
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Efficacy of Pemetrexed-based Chemotherapy in Comparison to Non-Pemetrexed-based Chemotherapy in Advanced, ALK+ Non-Small Cell Lung Cancer
Yonsei Medical Journal
2018 .01
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Safety evaluation of a novel TβRI/ALK5 inhibitor EW-7197
환경독성보건학회 심포지엄 및 학술대회
2014 .11
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