지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 791 - 796 (6page)
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초록· 키워드
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A 31-year-old Korean male presented with altered consciousness and severe headache.
Brain MRI delineated focal leptomeningeal enhancement without any intracerebral lesions. Diagnosis was made based on a brain biopsy showing anaplastic large cell lymphoma (ALCL), immunohistochemical stains revealing positivity for anaplastic lymphoma kinase (ALK) and an absence of involvement in any other organs;specifically, the primary central nervous system ALK+ALCL. Complete remission was achieved following 5 cycles of systemic chemotherapy with a high dose of Methotrexate and a simultaneous 7 cycles of intrathecal triple chemotherapy.
Diagnosis of primary leptomeningeal ALK+ALCL is challenging given its rarity and non-specific symptoms along with non-pathognomonic radiologic findings. We present the first case of primary leptomeningeal ALK-positive ALCL where the clinical course, pathologic characteristics and treatment modality are described as well as a review of literature.
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참고문헌 (21)
참고문헌 신청
Abdulkader I / 1999 / Primary anaplastic large cell lymphoma of the central nervous system / Hum Pathol 30 : 978 ~ 981
Buxton N / 1998 / Primary Ki-1-positive T-cell lymphoma of the brain in a child / Pediatr Neurosurg 29 : 250 ~ 252
Campo E / 2011 / The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications / Blood 117 : 5019 ~ 5032
Falini B / 1999 / ALK+ lymphoma: clinico-pathological findings and outcome / Blood 93 : 2697 ~ 2706
Felice MS / 2000 / Diagnosis and successful treatment of childhood primary leptomeningeal lymphoma / Med Pediatr Oncol 34 : 361 ~ 363
Buxton N / 1998 / Primary Ki-1-positive T-cell lymphoma of the brain in a child / Pediatr Neurosurg 29 : 250 ~ 252
Campo E / 2011 / The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications / Blood 117 : 5019 ~ 5032
Falini B / 1999 / ALK+ lymphoma: clinico-pathological findings and outcome / Blood 93 : 2697 ~ 2706
Felice MS / 2000 / Diagnosis and successful treatment of childhood primary leptomeningeal lymphoma / Med Pediatr Oncol 34 : 361 ~ 363
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