지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제26권 제11호
- 발행연도
- 2013.1
- 수록면
- 399 - 405 (7page)
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초록· 키워드
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Background : Several studies from western countries have reported variable prognoses for
patients with systemic anaplastic large cell lymphoma (ALCL) depending strongly on the expression
of anaplastic lymphoma kinase (ALK). However, no prognostic significance of ALK expression
in Koreans was reported in a single report regarding these patients, although the number
of cases was limited in that study. Methods : We analyzed the clinicopathological features of
ALK+ ALCL and ALK- ALCL in 30 Korean patients diagnosed with primary systemic ALCL.
Results : ALK expression was detected in 60% of all ALCL patients (18/30), and there was
no statistical significance to ALK expression in overall survival. Patients with ALK+ ALCL were
younger in age and had negative bcl-2 expression; these differences were statistically significant.
Tumors positive for ALK protein and granzyme B expression, and negative for bcl-2 expression
with a null-cell phenotype tended to have better survival outcomes, althought this trend
failed to reach statistical significance (p<0.2), probably due to the limited number of cases in
this study. Conclusion : ALK protein expression and the absence of bcl-2 in tumor cells tend
to result in better survival despite the failure of this trend to achieve statistical significance. Further
studies that examine potential pathologic prognostic factors combined with the expression
of ALK and apoptotic factors such as bcl-2 are needed. Additional larger-scale studies are also
needed to conclude that ALK expression has no prognostic significance among Koreans.
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참고문헌 (21)
참고문헌 신청
/ 1985 / The expression of the Hodgkin’sdisease associated antigen Ki-1 in reactive and neoplastic lymphoidtissue:evidence that Reed-Sternberg cells and histiocytic malignan
/ 1995 / Absence of the t(2; 5) in Hodgkin’s disease 85 : 2845 ~ 2847
/ 1995 / Anaplastic large celllymphomas expressing the novel chimeric protein p80NPM/ALK:a distinct clinicopathologic entity 86 : 1954 ~ 1960
/ 1996 / Molecular thanatopsis:a discourse on the BCL2 family and cell death 88 : 386 ~ 401
/ 1997 / Cross-resistance of CD95- and drug-induced apoptosis as a consequence of deficient activation of caspases(ICE/Ced-3 proteases) 90 : 3118 ~ 3129
/ 1995 / Absence of the t(2; 5) in Hodgkin’s disease 85 : 2845 ~ 2847
/ 1995 / Anaplastic large celllymphomas expressing the novel chimeric protein p80NPM/ALK:a distinct clinicopathologic entity 86 : 1954 ~ 1960
/ 1996 / Molecular thanatopsis:a discourse on the BCL2 family and cell death 88 : 386 ~ 401
/ 1997 / Cross-resistance of CD95- and drug-induced apoptosis as a consequence of deficient activation of caspases(ICE/Ced-3 proteases) 90 : 3118 ~ 3129
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