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논문 기본 정보
- 자료유형
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- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제48권 제1호
- 발행연도
- 2014.1
- 수록면
- 1 - 9 (9page)
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Rearrangement of anaplastic lymphoma kinase (ALK) gene is the best predictor of response to crizotinib, an ALK tyrosine kinase inhibitor. However, the prevalence of the ALK fusion is low, so accurate patient identification is crucial for successful treatment using ALK inhibitors. Furthermore, most patients with lung cancer present with advanced-stage disease at the time of diagnosis, so it is important for pathologists to detect ALK-rearranged patients while effectively maximizing small biopsy or cytology specimens. In this review, we propose a guideline recommendation for ALK testing approved by the Cardiopulmonary Pathology Study Group of the Korean Society of Pathologists.
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참고문헌 (21)
참고문헌 신청
Boland JM / 2009 / Anaplastic lymphoma kinase immunoreactivity correlates with ALK gene rearrangement and transcriptional up-regulation in non-small cell lung carcinomas / Hu
Inamura K / 2008 / EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers / J Thorac Oncol 3 : 13 ~ 17
Inamura K / 2009 / EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset / Mod Pathol 22 : 508 ~ 515
Jemal A / 2011 / Global cancer statistics / CA Cancer J Clin 61 : 69 ~ 90
Kargi A / 2007 / The diagno
Inamura K / 2008 / EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers / J Thorac Oncol 3 : 13 ~ 17
Inamura K / 2009 / EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset / Mod Pathol 22 : 508 ~ 515
Jemal A / 2011 / Global cancer statistics / CA Cancer J Clin 61 : 69 ~ 90
Kargi A / 2007 / The diagno
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