지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 998 - 1,009 (12page)
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초록· 키워드
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Purpose Tumor regression grade (TRG) is predictive of therapeutic response in rectal cancer patients after chemoradiotherapy (CRT) followed by curative resection. However, various TRG systems have been suggested, with subjective categorization, resulting in interobserver variability.
This study compared the prognostic validity of four different TRG systems in order to identify the most ideal TRG system.
Materials and Methods This study included 933 patients who underwent preoperative CRT and curative resection.
Primary tumors alone were graded according to the American Joint Committee on Cancer (AJCC), Dworak, and Ryan TRG systems, and both primary tumors and regional lymph nodes were graded according to a modified Dworak TRG system. The ability of each TRG system to predict recurrence-free survival (RFS) and overall survival (OS) was analyzed using chisquare and C statistics.
Results All four TRG systems were significantly predictive of both RFS and OS (p < 0.001 each), however none was a better predictor of prognosis than ypStage. Among the four TRGs, the mDworak TRG system was a better predictor of RFS and OS than the AJCC, Dworak, and Ryan TRG systems, and both the chi-square and C statistics were higher for the former, although the differences were not statistically significant. The combination of ypStage and the modified Dworak TRG better predicted RFS and OS than ypStage alone.
Conclusion The modified Dworak TRG system for evaluation of entire tumors including regional lymph nodes is a better predictor of survival than current TRG systems for evaluation of the primary tumor alone.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Quah HM / 2008 / Pathologic stage is most prognostic of disease-free survival in locally advanced rectal cancer patients after preoperative chemoradiation / Cancer 113:57~64
Hermanek P / 2013 / Prognosis of rectal carcinoma after multimodal treatment : ypTNM classification and tumor regression grading are essential / Anticancer Res 33:559~566
Kim DW / 2006 / Is T classification still correlated with lymph node status after preoperative chemoradiotherapy for rectal cancer? / Cancer 106:1694~1700
Vecchio FM / 2005 / The relationship of pathologic tumor regression grade(TRG)and outcomes after preoperative therapy in rectal cancer / Int J Radiat Oncol Biol Phys 62:752~760
Edge SB / 2010 / AJCC cancer staging manual / Springer-Verlag
Hermanek P / 2013 / Prognosis of rectal carcinoma after multimodal treatment : ypTNM classification and tumor regression grading are essential / Anticancer Res 33:559~566
Kim DW / 2006 / Is T classification still correlated with lymph node status after preoperative chemoradiotherapy for rectal cancer? / Cancer 106:1694~1700
Vecchio FM / 2005 / The relationship of pathologic tumor regression grade(TRG)and outcomes after preoperative therapy in rectal cancer / Int J Radiat Oncol Biol Phys 62:752~760
Edge SB / 2010 / AJCC cancer staging manual / Springer-Verlag
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