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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 78 - 89 (12page)
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Purpose Patients show variable responses to chemoradiotherapy (CRT), which is generally administeredbefore surgery for locally advanced rectal cancer (LARC). The aim of this study was toidentify molecular markers predictive of CRT responses by analysis of low-mass ions (LMIs)in serum of LARC patients.
Materials and MethodsLMIs (< 1,000 m/z) in serum obtained before CRT from 73 LARC (cT3-4) patients wereprofiled using matrix-assisted laser desorption/ionization mass spectrometry. LMIs withhigher weighting factors in discriminating CRT responses were selected using principalcomponents analysis and discriminant analysis. Selected LMIs were identified using theHuman Metabolome Database. The concentrations of identified LMIs were determined bycolorimetric enzyme assay, and compared according to post-CRT pathological stage(ypStage) or Dworak’s tumor regression grade (TRG).
ResultsThe nine highest-ranking LMIs were selected. Among them, two LMIs with 137.08 and169.04 m/z were identified as hypoxanthine (HX) and phosphoenolpyruvic acid (PEP),respectively. Higher HX concentration was observed in patients with ypStage 0-1 comparedto ypStage 2-4 (p=0.034) or ypStage 3-4 (p=0.030); a similar difference was observedbetween TRG 4-3 and TRG 1 (p=0.035). HX > 16.0 μM showed significant association withypStage 0-1 or TRG 4-3 than ypStage 3-4 (p=0.009) or TRG 1 (p=0.024), respectively. Incontrast, a significantly lower concentration of PEP was observed in TRG 4-3 compared withTRG 2-1 (p=0.012).
ConclusionFindings of this study demonstrated that serum concentrations of HX and PEP, identifiedusing LMI profiling, may be useful for predicting the CRT response of LARC patients beforetreatment.
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참고문헌 (20)
참고문헌 신청
Chihwan Choi / 2012 / Clinical predictive factors of pathologic tumor response after preoperative chemoradiotherapy in rectal cancer / Radiation oncology journal 30 (3) : 99
Christofk HR / 2008 / The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth / Nature 452 : 230 ~ 233
Cooper RA / 1967 / The direct synthesis of phosphoenolpyruvate from pyruvate by Escherichia coli / Proc R Soc Lond B Biol Sci 168 : 263 ~ 280
Dworak O / 1997 / Pathological features of rectal cancer after preoperative radiochemotherapy / Int J Colorectal Dis 12 : 19 ~ 23
Edge S / 2010 / AJCC cancer staging manual / Springer : 143 ~ 164
Christofk HR / 2008 / The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth / Nature 452 : 230 ~ 233
Cooper RA / 1967 / The direct synthesis of phosphoenolpyruvate from pyruvate by Escherichia coli / Proc R Soc Lond B Biol Sci 168 : 263 ~ 280
Dworak O / 1997 / Pathological features of rectal cancer after preoperative radiochemotherapy / Int J Colorectal Dis 12 : 19 ~ 23
Edge S / 2010 / AJCC cancer staging manual / Springer : 143 ~ 164
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