지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제56권 제1호
- 발행연도
- 2022.1
- 수록면
- 40 - 47 (8page)
- DOI
- 10.4132/jptm.2021.10.07
이용수
초록· 키워드
오류제보하기
Background: Polo-like kinase 4 (PLK4) is a serine/threonine protein kinase located in the centriole of the chromosome during the cell cycle. PLK4 overexpression has been described in a variety of many common human epithelial tumors. Conversely, PLK4 acts as a haploinsufficient tumor suppressor in some situations, highlighting the importance of strict regulation of PLK4 expression, activity, and function. Meanwhile, the importance of chemoradiation resistance in rectal cancer is being emphasized more than ever. We aimed to analyze PLK4 expression and the tumor regression grade (TRG) in patients with rectal cancer, treated with chemoradiotherapy (CRT).Methods: A retrospective study was conducted on 102 patients with rectal cancer who received preoperative CRT. Immunohistochemistry for PLK4 in paraffin-embedded tissue was performed from the biopsy and surgical specimens. Results: We found significant association between high expression of PLK4 and poor response to neoadjuvant CRT (according to both Mandard and The Korean Society of Pathologists TRG systems) in the pre-CRT specimens. Other clinicopathologic parameters did not reveal any correlation with PLK4 expression. Conclusions: This study revealed an association between high expression of PLK4 in the pre-CRT specimens and TRG. Our results indicated that PLK4 could potentially be a new predictor for CRT effect in patients with rectal cancer.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
PLK2 Single Nucleotide Variant in Gastric Cancer Patients Affects miR-23b-5p Binding
Journal of Gastric Cancer
2022 .10
-
Polo-Like Kinase 1 Regulates Chromosomal Instability and Paclitaxel Resistance in Breast Cancer Cells
Journal of Breast Cancer
2022 .06
-
Expression of polo-like kinase 1 in pre-implantation stage murine somatic cell nuclear transfer embryos
Journal of Veterinary Science
2019 .01
-
Difference in Tumor Area as a Predictor of a Pathological Complete Response for Patients With Locally Advanced Rectal Cancer
Annals of Coloproctology
2017 .01
-
Correlation between tumor regression grade and rectal volume in neoadjuvant concurrent chemoradiotherapy for rectal cancer
Radiation oncology journal : ROJ
2016 .01
-
New Perspectives on Predictive Biomarkers of Tumor Response and Their Clinical Application in Preoperative Chemoradiation Therapy for Rectal Cancer
Yonsei Medical Journal
2015 .01
-
Early Systemic Failure After Preoperative Chemoradiotherapy for the Treatment of Patients With Rectal Cancer
Annals of Coloproctology
2019 .01
-
Effect of leukocyte alteration on treatment outcomes following preoperative chemoradiotherapy in patients with rectal cancer
Radiation oncology journal : ROJ
2017 .01
-
Clinical influence of neoadjuvant chemoradiotherapy on immunonutritional status in locally advanced rectal cancer
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2023 .06
-
What Is the Ideal Tumor Regression Grading System in Rectal Cancer Patients after Preoperative Chemoradiotherapy?
Cancer Research and Treatment
2016 .01
-
Matched case-control analysis comparing oncologic outcomes between preoperative and postoperative chemoradiotherapy for rectal cancer
Annals of Surgical Treatment and Research
2017 .04
-
Impact of circumferential tumor location of mid to low rectal cancer on oncologic outcomes after preoperative chemoradiotherapy
Annals of Surgical Treatment and Research
2022 .08
-
Endoscopic Criteria for Evaluating Tumor Stage after Preoperative Chemoradiation Therapy in Locally Advanced Rectal Cancer
Cancer Research and Treatment
2016 .01
-
Identification of Hypoxanthine and Phosphoenolpyruvic Acid as Serum Markers of Chemoradiotherapy Response in Locally Advanced Rectal Cancer
Cancer Research and Treatment
2015 .01
-
Sustaining Blood Lymphocyte Count during Preoperative Chemoradiotherapy as a Predictive Marker for Pathologic Complete Response in Locally Advanced Rectal Cancer
Cancer Research and Treatment
2016 .01
-
An investigation into tumor regression grade as a parameter for locally advanced rectal cancer and 5-year overall survival rate
Annals of Coloproctology
2023 .02
-
Prediction of Pathologic Response to Neoadjuvant Chemoradiotherapy in Patients with Esophageal Squamous Cell Carcinoma Incorporating Hematological Biomarkers
Cancer Research and Treatment
2021 .01
-
Nodal tumor response according to the count of peripheral blood lymphocyte subpopulations during preoperative chemoradiotherapy in locally advanced rectal cancer
Radiation oncology journal : ROJ
2016 .01
-
Comparison of Chemoradiation Therapy vs. Adjuvant Chemotherapy Alone in Patients with Extremely Low Rectal Cancer Requiring Abdominoperineal Resection
대한외과학회 학술대회 초록집
2021 .05
-
The pattern of bowel dysfunction in patients with rectal cancer following the multimodal treatment: anorectal manometric measurements at before and after chemoradiation therapy, and postoperative 1 year
Annals of Coloproctology
2023 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0