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논문 기본 정보

자료유형
학술저널
저자정보
Yusuf Sahin (Bagcilar Training and Research Hospital) Ugur Yucetas (Istanbul Training and Research Hospital) Huseyin Aytaç Ates (Gebze Fatih State Hospital) Erkan Erkan (Istanbul Training and Research Hospital) Esma Yucetas (Haseki Training and Research Hospital) Mustafa Zafer Temiz (Bagcilar Training and Research Hospital) Mahmut Gokhan Toktas (Istanbul Training and Research Hospital) Mustafa Kadihasanoglu (Istanbul Training and Research Hospital) Birsen Cigdem Topkaya (Istanbul Training and Research Hospital)
저널정보
대한비뇨기과학회 Investigative and Clinical Urology Investigative and Clinical Urology Vol.60 No.5
발행연도
2019.1
수록면
343 - 350 (8page)

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Purpose: To investigate whether measurement of urinary calprotectin can serve as a biomarker in the diagnosis of primary bladder cancer and to confirm its diagnostic role in determining high grade and stage disease. Materials and Methods: Urinary calprotectin was measured in spot urine samples from patients with primary bladder cancer and control subjects. To confirm levels in urine, tissue samples were also obtained from bladder tumor and healthy trigone of bladder by transurethral resection in both groups. Finally, calprotectin levels in tissue and urine of the patients and control subjects were compared and their diagnostic potential was investigated in high grade and stage bladder cancers. Results: Of 82 participants, 52 were patients with bladder cancer and 30 were control subjects. The two groups were comparable in terms of age, smoking status, and comorbidities. Tissue and urinary calprotectin levels were significantly higher in the bladder cancer group. In subgroup analyses, urinary calprotectin levels were significantly higher in patients with high-grade, muscle-invasive tumors. After receiver operating characteristic analyses, the sensitivity and specificity of urinary calprotectin was 100% and 96.7%, respectively, in the diagnosis of primary bladder cancer. High grade and stage bladder cancers were detected with sensitivity and specificity of 70% and 74.2%, and 80% and 84.8%, respectively. Conclusions: Urinary calprotectin may be a valuable parameter in the diagnosis of primary bladder cancer with high sensitivity and specificity. Furthermore, it may be useful in the prediction of high grade and stage disease. However, more investigations are needed.
#Biomarkers #Calprotectin #Urinary bladder neoplasms #Urine

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참고문헌 (25)

참고문헌 신청
Ferlay J / 2018 / Cancer incidence and mortality worldwide : sources, methods and major patterns in GLOBOCAN 2012 / Int J Cancer 136:E359~E386 google schola Compérat E / 2015 / Clinicopathological characteristics of urothelial bladder cancer in patients less than 40 years old / Virchows Arch 466:589~594 google schola Burger M / 2013 / Epidemiology and risk factors of urothelial bladder cancer / Eur Urol 63:234~241 google schola Wakai K / 2016 / Clinical predictors for high-grade bladder cancer before firsttime transurethral resection of the bladder tumor : a retrospective cohort study / Jpn J Clin Oncol 46:964~967 google schola Yafi FA / 2014 / Is the performance of urinary cytology as high as reported historically? A contemporary analysis in the detection and surveillance of bladder cancer / Urol Oncol 32:27.e1~27.e6 google schola

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