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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 230 - 234 (5page)
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Interferon-alpha (IFN-α) is an important therapeutic agent for hepatitis C virus (HCV) infection, but has various side effects including thyroiditis. We report a case of interferon-induced non-autoimmune hypothyroidism followed by autoimmune-medicated Graves’ disease. A 59-year-old woman was diagnosed with chronic active hepatitis C; she had been treated with IFN-α and ribavirin for 24 weeks. Before starting the IFN-α, her thyroid function was normal and she was negative for autoantibodies. Severe hypothyroidism developed 5 weeks after halting the IFN-α, with the Graves’ disease phase arising at 32 weeks. For accurate diagnosis and appropriate treatment of thyroid dysfunction during treatment with IFN-α, we need to understand and consider rare cases of multiphasic disorder involving both non-autoimmune and autoimmune thyroiditis induced by IFN-α.
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참고문헌 (20)
참고문헌 신청
Akeno N / 2011 / IFN-alpha mediates the development of autoimmunity both by direct tissue toxicity and through immune cell recruitment mechanisms / J Immunol 186 (8) : 4693 ~
Barut ? / 2013 / Thyroid disorders associated with hepatitis C or interferon based therapies / J Microbiol Infect Dis 3 (3) : 147 ~ 149
Bohbot NL / 2006 / Interferon-alpha-induced hyperthyroidism:a three-stage evolution from silent thyroiditis towards Graves' disease / Eur J Endocrinol 154 (3) : 367 ~ 372
Caraccio N / 2009 / Effect of type I interferon(s) on cell viability and apoptosis in primary human thyrocyte cultures / Thyroid 19 (2) : 149 ~ 155
Carella C / 2001 / Long-term outcome of interferon-alphainduced thyroid autoimmunity and prognostic influence of thyroid autoantibody pattern at the end of treatment / J Cli
Barut ? / 2013 / Thyroid disorders associated with hepatitis C or interferon based therapies / J Microbiol Infect Dis 3 (3) : 147 ~ 149
Bohbot NL / 2006 / Interferon-alpha-induced hyperthyroidism:a three-stage evolution from silent thyroiditis towards Graves' disease / Eur J Endocrinol 154 (3) : 367 ~ 372
Caraccio N / 2009 / Effect of type I interferon(s) on cell viability and apoptosis in primary human thyrocyte cultures / Thyroid 19 (2) : 149 ~ 155
Carella C / 2001 / Long-term outcome of interferon-alphainduced thyroid autoimmunity and prognostic influence of thyroid autoantibody pattern at the end of treatment / J Cli
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