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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 381 - 390 (10page)
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초록· 키워드
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Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I and III interferon (IFN) responses act as the first line of defense against viral infection and are activated by the recognition of viruses by infected cells and innate immune cells. Dysregulation of host IFN responses has been known to be associated with severe disease progression in COVID-19 patients. However, the reported results are controversial and the roles of IFN responses in COVID-19 need to be investigated further. In the absence of a highly efficacious antiviral drug, clinical studies have evaluated recombinant type I and III IFNs, as they have been successfully used for the treatment of infections caused by two other epidemic coronaviruses, SARS-CoV-1 and Middle East respiratory syndrome (MERS)-CoV. In this review, we describe the strategies by which SARS-CoV-2 evades IFN responses and the dysregulation of host IFN responses in COVID-19 patients. In addition, we discuss the therapeutic potential of type I and III IFNs in COVID-19.
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참고문헌 (99)
참고문헌 신청
Zhu N / 2020 / A novel coronavirus from patients with pneumonia in China, 2019 / N Engl J Med 382:727~733
Lu R / 2020 / Genomic characterisation and epidemiology of 2019 novel coronavirus : implications for virus origins and receptor binding / Lancet 395:565~574
Wan Y / 2020 / Receptor recognition by the novel coronavirus from Wuhan : an analysis based on decadelong structural studies of SARS coronavirus / J Virol 94:e00127~20
Fung TS / 2019 / Human coronavirus : host-pathogen interaction / Annu Rev Microbiol 73:529~557
Fauci AS / 2020 / COVID-19-navigating the uncharted / N Engl J Med 382:1268~1269
Lu R / 2020 / Genomic characterisation and epidemiology of 2019 novel coronavirus : implications for virus origins and receptor binding / Lancet 395:565~574
Wan Y / 2020 / Receptor recognition by the novel coronavirus from Wuhan : an analysis based on decadelong structural studies of SARS coronavirus / J Virol 94:e00127~20
Fung TS / 2019 / Human coronavirus : host-pathogen interaction / Annu Rev Microbiol 73:529~557
Fauci AS / 2020 / COVID-19-navigating the uncharted / N Engl J Med 382:1268~1269
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