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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 247 - 249 (3page)
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In this study we evaluated the role of a candidate gene for major psychosis, Sialyltransferase (ST8SIA2), in the risk to develop a schizophrenia spectrum disorders, taking into account exposure to stressful life events (SLEs). Eight polymorphisms (SNPs) were tested in 94 Schizophreniainpatients and 176 healthy controls. Schizophrenia patients were also evaluated for SLEs in different life periods. None of the SNPs showed association with schizophrenia. Nevertheless, when crossing genetic variants with childhood SLEs, we could observe trends of interaction with age of onset. Though several limitations, our results support a protective role of ST8SIA2 in individuals exposed to moderate childhood stress.
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등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Sadock BJ / 2008 / Concise Textbook of Clinical Psychiatry / Lippicott & Wilkins
Lang UE / 2007 / Molecular mechanisms of schizophrenia / Cell Physiol Biochem 20:687~702
Roussos P / 2014 / Schizophrenia : susceptibility genes and oligodendroglial and myelin related abnormalities / Front Cell Neurosci 8:5
Iyegbe C / 2014 / The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for GxE research / Soc Psychiatry Psychiatr Epidemiol 49:169~182
Tienari P / 2003 / Genetic boundaries of the schizophrenia spectrum : evidence from the Finnish Adoptive Family Study of Schizophrenia / Am J Psychiatry 160:1587~1594
Lang UE / 2007 / Molecular mechanisms of schizophrenia / Cell Physiol Biochem 20:687~702
Roussos P / 2014 / Schizophrenia : susceptibility genes and oligodendroglial and myelin related abnormalities / Front Cell Neurosci 8:5
Iyegbe C / 2014 / The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for GxE research / Soc Psychiatry Psychiatr Epidemiol 49:169~182
Tienari P / 2003 / Genetic boundaries of the schizophrenia spectrum : evidence from the Finnish Adoptive Family Study of Schizophrenia / Am J Psychiatry 160:1587~1594
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