지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 619 - 625 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: Schizophrenia is a devastating mental disorder and is known to be affected by genetic factors. The chromogranin B (CHGB), a member of the chromogranin gene family, has been proposed as a candidate gene associated with the risk of schizophrenia.
The secretory pathway for peptide hormones and neuropeptides in the brain is regulated by chromogranin proteins. The aim of this study was to investigate the potential associations between genetic variants of CHGB and schizophrenia susceptibility.
Materials and Methods: In the current study, 15 single nucleotide polymorphisms of CHGB were genotyped in 310 schizophreniapatients and 604 healthy controls.
Results: Statistical analysis revealed that two genetic variants (non-synonymous rs910122; rs2821 in 3’-untranslated region) were associated with schizophrenia [minimum p=0.002; odds ratio (OR)=0.72], even after correction for multiple testing (pcorr=0.02). Since schizophrenia is known to be differentially expressed between sexes, additional analysis for sex was performed. As a result, these two genetic variants (rs910122 and rs2821) and a haplotype (ht3) showed significant associations with schizophrenia in male subjects (pcorr=0.02; OR=0.64), whereas the significance disappeared in female subjects (p>0.05).
Conclusion: Although this study has limitations including a small number of samples and lack of functional study, our results suggest that genetic variants of CHGB may have sex-specific effects on the risk of schizophrenia and provide useful preliminary information for further study.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Aleman A / 2003 / Sex differences in the risk of schizophrenia:evidence from meta-analysis / Arch Gen Psychiatry 60 : 565 ~ 571
American Psychiatric Association / 1994 / Diagnostic and Statistical Manual of Mental Disorders: DSM-IV / American Psychiatric Association
Barrett JC / 2005 / Haploview: analysis and visualization of LD and haplotype maps / Bioinformatics 21 : 263 ~ 265
Chen XW / 2008 / DTNBP1, a schizophrenia susceptibility gene, affects kinetics of transmitter release / J Cell Biol 181 : 791 ~ 801
Gamo NJ / 2013 / Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunction / Transl Psychiatry 3 : e328 ~
American Psychiatric Association / 1994 / Diagnostic and Statistical Manual of Mental Disorders: DSM-IV / American Psychiatric Association
Barrett JC / 2005 / Haploview: analysis and visualization of LD and haplotype maps / Bioinformatics 21 : 263 ~ 265
Chen XW / 2008 / DTNBP1, a schizophrenia susceptibility gene, affects kinetics of transmitter release / J Cell Biol 181 : 791 ~ 801
Gamo NJ / 2013 / Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunction / Transl Psychiatry 3 : e328 ~
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
한국인 조현병 환자에서 Chromogranin B 유전자와 안구운동 이상의 연합에 대한 연구
생물정신의학
2018 .01
-
조현병과 제1형 양극성장애의 진단 경계를 넘어선 공통적 후보유전자로서의CACNA1C 에 대한 단일염기다형성 연합 연구
대한조현병학회지
2018 .01
-
“Food for Thought”: Improving Cognition in People With Schizophrenia
PSYCHIATRY INVESTIGATION
2024 .08
-
유럽인 자료로 산출된 조현병 다유전자 위험도 점수의 한국인 조현병 환자를 대상으로 한 적용
대한조현병학회지
2020 .01
-
Clinical Strategies in Gene Screening Counseling for the Healthy General Population
Korean Journal of Family Medicine
2024 .03
-
Navigating the landscape of clinical genetic testing: insights and challenges in rare disease diagnostics
Childhood Kidney Diseases
2024 .02
-
Age of Onset in Schizophrenia Spectrum Disorders: Complex Interactions between Genetic and Environmental Factors
PSYCHIATRY INVESTIGATION
2016 .01
-
Genetic quality control of laboratory animal
한국실험동물학회 학술발표대회 논문집
2017 .08
-
Reduction in Alpha Peak Frequency and Coherence on Quantitative Electroencephalography in Patients with Schizophrenia
Journal of Korean Medical Science
2018 .01
-
Genetic monitoring of laboratory animal
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Molecular Genetics of von Willebrand Disease in Korean Patients: Novel Variants and Limited Diagnostic Utility of Multiplex Ligation-Dependent Probe Amplification Analyses
Annals of Laboratory Medicine
2019 .01
-
조현병과 뇌파
신경정신의학
2019 .01
-
Clinical Implications of Single Nucleotide Polymorphisms in Diagnosis of Asthma and its Subtypes
Yonsei Medical Journal
2019 .01
-
Association Study between Norepinephrine Transporter Gene Polymorphism and Schizophrenia in a Korean Population
PSYCHIATRY INVESTIGATION
2015 .01
-
Long-Term Outcomes of Genetic Parkinson’s Disease
Journal Of Movement Disorders
2020 .01
-
Variants of Lipolysis-Related Genes in Korean Patients with Very High Triglycerides
Yonsei Medical Journal
2018 .01
-
Challenges and Considerations in Sequence Variant Interpretation for Mendelian Disorders
Annals of Laboratory Medicine
2019 .01
-
항정신병약물에 의한 대사부작용에 대한 이론과 대처방안
신경정신의학
2019 .01
-
Report of the Korean Association of External Quality Assessment Service on Next-Generation Sequencing Analysis for Somatic Variants (2018–2020)
Journal of Laboratory Medicine And Quality Assurance
2021 .01
-
Germline pathogenic variants in unselected Korean men with prostate cancer
Investigative and Clinical Urology
2022 .05
이 논문의 저자 정보
최근 본 자료
댓글(0)
0