지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 164 - 171 (8page)
이용수
초록· 키워드
오류제보하기
Background and Purpose Te aim of this study was to determine the efcacy and tolerability of granulocyte colony-stimulating factor (G-CSF) in subjects with amyotrophic lateralsclerosis (ALS).
Methods Forty subjects with ALS were randomly assigned to two groups, which received either subcutaneous G-CSF (5 μg/kg/q12h) or placebo for 5 days. Te subjects were then followed up for 3 months using the ALS Functional Rating Scale-Revised (ALSFRS-R), manualmuscle testing, ALS Assessment Questionnaire-40, and nerve conduction studies. CD34+/CD133+ cell count and monocyte chemoattractant protein-1 (MCP-1) levels were evaluated atbaseline.
Results Te rate of disease progression did not difer signifcantly between the two groups.
Te reduction in ALSFRS-R scores was greater in female subjects in the G-CSF group than intheir counterparts in the placebo group. Tere was a trend toward a positive correlation between baseline CSF MCP-1 levels and the change in ALSFRS-R scores in both groups (Spearman’s ρ=0.370, p=0.070).
Conclusions With the protocol implemented in this study, G-CSF is not a promising optionfor the treatment of ALS. Furthermore, it may accelerate disease progression in females.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Chio A / 2009 / Prognostic factors in ALS: A critical review / Amyotroph Lateral Scler 10 : 310 ~
Chio A / 2011 / Repeated courses of granulocyte colony-stimulating factor in amyotrophic lateral sclerosis: clinical and biological results from a prospective multicenter st
Duning T / 2011 / G-CSF prevents the progression of structural disintegration of white matter tracts in amyotrophic lateral sclerosis: a pilot trial / PLoS One 6 : e17770 ~
Franchignoni F / 2013 / Evidence of multidimensionality in the ALSFRS-R Scale: a critical appraisal on its measurement properties using Rasch analysis / J Neurol Neurosurg P
Great Lakes ALS Study Group / 2003 / A comparison of muscle strength testing techniques in amyotrophic lateral sclerosis / Neurology 61 : 1503 ~ 1507
Chio A / 2011 / Repeated courses of granulocyte colony-stimulating factor in amyotrophic lateral sclerosis: clinical and biological results from a prospective multicenter st
Duning T / 2011 / G-CSF prevents the progression of structural disintegration of white matter tracts in amyotrophic lateral sclerosis: a pilot trial / PLoS One 6 : e17770 ~
Franchignoni F / 2013 / Evidence of multidimensionality in the ALSFRS-R Scale: a critical appraisal on its measurement properties using Rasch analysis / J Neurol Neurosurg P
Great Lakes ALS Study Group / 2003 / A comparison of muscle strength testing techniques in amyotrophic lateral sclerosis / Neurology 61 : 1503 ~ 1507
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Decreased Serum Monocyte Chemoattractant Protein-1 in Salivary Gland Tumor Patients
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
The Correlation Study between Plasma Aβ Proteins and Cerebrospinal Fluid Alzheimer’s Disease Biomarkers
Dementia and Neurocognitive Disorders(대한치매학회지)
2016 .12
-
Retrospective Analysis of Cerebrospinal Fluid Profiles in 228 Patients with Leptomeningeal Carcinomatosis : Differences According to the Sampling Site, Symptoms, and Systemic Factors
대한신경외과학회지
2016 .01
-
B세포림프종 환자에서 혈청 대식세포집락자극인자 농도 증가와 임상병리학적 특징의 연관성
Laboratory Medicine Online
2021 .01
-
Circulating Monocyte Chemoattractant Protein-1 Levels and Lumbar Bone Mineral Density in Korean Women
Journal of Obesity & Metabolic Syndrome
2017 .01
-
Serial Changes of Cytokines in Children with Cerebral Palsy Who Received Intravenous Granulocyte-colony Stimulating Factor Followed by Autologous Mobilized Peripheral Blood Mononuclear Cells
Journal of Korean Medical Science
2018 .01
-
Cerebrospinal Biomarker Cut-off Methods Defined Only by Alzheimer’s Disease Predict More Precisely Conversions of Mild Cognitive Impairment
Dementia and Neurocognitive Disorders(대한치매학회지)
2017 .01
-
Combined Effect of Granulocyte-Colony-Stimulating Factor-Induced Bone Marrow-Derived Stem Cells and Red Ginseng in Patients with Decompensated Liver Cirrhosis (Combined Effect of G-CSF and Red Ginseng in Liver Cirrhosis)
대한한의학회지
2016 .12
-
Toward the development of a one-dose classical swine fever subunit vaccine
Journal of Veterinary Science
2018 .05
-
Prognostic Role of Serum Levels of Uric Acid in Amyotrophic Lateral Sclerosis
Journal of Clinical Neurology
2015 .01
-
Chitinase-3-like protein 1, matrix metalloproteinase-9, and monocyte chemoattractant protein-1 as potential biomarkers and treatment targets of adenomyosis
Obstetrics & Gynecology Science
2024 .07
-
운동치료가 근위축성측삭경화증 환자 삶의 질에 미치는 영향: 예비연구
대한근전도 전기진단의학회지
2018 .01
-
Role of MicroRNA-34a in Anti-Apoptotic Effects of Granulocyte-Colony Stimulating Factor in Diabetic Cardiomyopathy
Diabetes and Metabolism Journal
2020 .01
-
유방암으로 항암 치료받는 환자에서 발생하는 과도한 골수 억제의 예측인자
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2016 .06
-
Effect of Serum Perampanel Concentration on Sporadic Amyotrophic Lateral Sclerosis Progression
Journal of Clinical Neurology
2023 .05
-
Extended Culture of Bone Marrow with Granulocyte Macrophage-Colony Stimulating Factor Generates Immunosuppressive Cells
Immune Network
2018 .04
-
Nuclear factor kappa-B- and activator protein-1-mediated immunostimulatory activity of compound K in monocytes and macrophages
Journal of Ginseng Research
2017 .07
-
Detection of Glioma-Related Hotspot Mutations Through Sequencing of Cerebrospinal Fluid (CSF)-Derived Circulating Tumor DNA: A Pilot Study on CSF-Based Liquid Biopsy for Primary Spinal Cord Astrocytoma
Neurospine
2023 .06
-
Comparison of Non-Invasive Clinical Algorithms for Liver Fibrosis in Patients With Chronic Hepatitis B to Reduce the Need for Liver Biopsy: Application of Enhanced Liver Fibrosis and Mac-2 Binding Protein Glycosylation Isomer
Annals of Laboratory Medicine
2022 .03
-
Serum interferon-γ and urinary monocyte chemoattractant peptide-1 are important factors in the pathogenesis of IgA nephropathy
Kidney Research and Clinical Practice
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0