지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.5
- 수록면
- 280 - 287 (8page)
이용수
초록· 키워드
오류제보하기
Background and Purpose To clarify the effect of perampanel (PER) on sporadic amyotrophic lateral sclerosis (sALS) progression, the relationship between the changes in Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) scores and serum PER concentrations was investigated.
Methods 12 patients with sALS from our hospital who agreed to participate and completed the PER for sALS randomized phase 2 study were included. After completing the study, we retrospectively obtained serum PER concentration data from the patients. Based on their mean PER concentrations, we divided the patients who had been taking PER into two groups: four patients with a mean PER concentration of ≥400 ng/mL were assigned to the H group, and three with a mean PER concentration of <400 ng/mL were assigned to the L group. The control group consisted of five patients who had been taking a placebo. We obtained the ALSFRS-R scores of each patient at 36 and 48 weeks after randomization. The differences in ALSFRS-R scores at baseline (0 weeks) and each subsequent week were used in the analysis.
Results At 48 weeks, there were no differences in the degree of deterioration of the bulbar, upper and lower limb, and respiratory ALSFRS-R subscores and total ALSFRS-R score. However, at 36 weeks, the bulbar subscore was significantly lower in the H group than in the control group (p=0.032).
Conclusions Because high PER concentrations may exacerbate bulbar symptoms in patients with sALS, serum PER measurements may be beneficial when patients with sALS are taking PER.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
태양인 해역증으로 진단한 근위축성 측삭경화증 환자 치험 1례
JSCM : Journal of Sasang constitutional medicine
2016 .01
-
운동치료가 근위축성측삭경화증 환자 삶의 질에 미치는 영향: 예비연구
대한근전도 전기진단의학회지
2018 .01
-
Newly Diagnosed Amyotrophic Lateral Sclerosis in a Patient with Multiple-System Atrophy
Journal of Clinical Neurology
2020 .01
-
한방 치료로 호전된 근위축성측색경화증에 대한 증례 1례 : 증례보고
대한한방내과학회지
2022 .10
-
Ocular Involvement Occurs Frequently at All Stages of Amyotrophic Lateral Sclerosis: Preliminary Experience in a Large Italian Cohort
Journal of Clinical Neurology
2021 .01
-
Withdrawal of Life-Sustaining Mechanical Ventilation for a Patient With Amyotrophic Lateral Sclerosis in Locked-In Syndrome
Journal of Clinical Neurology
2024 .09
-
근위축성측삭경화증(Amyotrophic Lateral Sclerosis) 환자들의 인구사회학적 요인에 따른 생존의 차이
대한직업환경의학회 학술대회 논문집
2017 .11
-
A case report on the use of processed Glycyrrhiza uralensis extract and Korean medical treatment for a patient with Amyotrophic Lateral Sclerosis(ALS)
대한침구의학회지
2016 .01
-
Long-Term Outcome of Amyotrophic Lateral Sclerosis in Korean Subjects
Annals of Rehabilitation Medicine
2017 .01
-
First Case of TARDBP-Related Amyotrophic Lateral Sclerosis in Korea
Journal of Clinical Neurology
2020 .01
-
흰쥐에서 SAL5의 알코올성 지방간 형성에 미치는 영향
대한본초학회지(본초분과학회지)
2018 .01
-
Percutaneous radiologic gastrostomy in patients with amyotrophic lateral sclerosis: A safe and effective technique
International Journal of Gastrointestinal Intervention
2021 .01
-
Recognized cases of amyotrophic lateral sclerosis in automobile workers by the Korean Epidemiologic Investigation Evaluation Committee
대한직업환경의학회지
2024 .12
-
Juvenile systemic sclerosis
대한류마티스학회지
2024 .04
-
Clinical Course of Amyotrophic Lateral Sclerosis according to Initial Symptoms: An Analysis of 500 Cases
Yonsei Medical Journal
2021 .01
-
Reliability and Validity of the Korean Version of the Spinal and Bulbar Muscular Atrophy Functional Rating Scale
Journal of Clinical Neurology
2020 .01
-
Prognostic Role of Serum Levels of Uric Acid in Amyotrophic Lateral Sclerosis
Journal of Clinical Neurology
2015 .01
-
Prolyl Isomerase Pin1 Expression in the Spinal Motor Neurons of Patients With Sporadic Amyotrophic Lateral Sclerosis
Journal of Clinical Neurology
2022 .07
-
Impaired Nucleoporins Are Present in Sporadic Amyotrophic Lateral Sclerosis Motor Neurons that Exhibit Mislocalization of the 43-kDa TAR DNA-Binding Protein
Journal of Clinical Neurology
2019 .01
-
Spinal anesthesia for cesarean section in a patient with systemic sclerosis associated interstitial lung disease -a case report-
Korean Journal of Anesthesiology
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0