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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 36 - 44 (9page)
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Objectives: Granulocyte-colony-stimulating factor (G-CSF) mobilized bone marrow (BM)-derived hematopoietic stem cells could contribute to improvement of liver function. In addition, liver fibrosis can reportedly be prevented by the Rg 1 component of red ginseng. This study investigated the combined effect of G-CSF and red ginseng on decompensated liver cirrhosis.
Methods: Four patients with decompensated liver cirrhosis were injected with G-CSF to proliferate BM stem cells for 4 days (5 μg/kg bid subcutaneously) and followed-up for 3 months. The patients also received red ginseng for 4 days (2 tablets tid per os). We analyzed Child-Pugh scores, Model for End-Stage Liver Disease (MELD) scores and cirrhotic complications.
Results: All patients showed marked increases in White blood cell (WBC) and CD34+ cells in the peripheral blood, with a peak time of 4 days after G-CSF injection. Spleen size also increased after G-CSF injection, but not severely. At end of the study, 2 patients showed improvement in Child-Pugh scores, hepatic encephalopathy, and refractory ascites. During the clinical trial period, none of the 4 patients showed any other adverse events or deterioration of liver function.
Conclusions: We conclude that G-CSF/red ginseng combination therapy is relatively effective in improving liver function and major complications of decompensated liver cirrhosis without adverse effects. Further clinical trials are warranted to assess the clinical effects of G-CSF for decompensated liver cirrhosis.
Methods: Four patients with decompensated liver cirrhosis were injected with G-CSF to proliferate BM stem cells for 4 days (5 μg/kg bid subcutaneously) and followed-up for 3 months. The patients also received red ginseng for 4 days (2 tablets tid per os). We analyzed Child-Pugh scores, Model for End-Stage Liver Disease (MELD) scores and cirrhotic complications.
Results: All patients showed marked increases in White blood cell (WBC) and CD34+ cells in the peripheral blood, with a peak time of 4 days after G-CSF injection. Spleen size also increased after G-CSF injection, but not severely. At end of the study, 2 patients showed improvement in Child-Pugh scores, hepatic encephalopathy, and refractory ascites. During the clinical trial period, none of the 4 patients showed any other adverse events or deterioration of liver function.
Conclusions: We conclude that G-CSF/red ginseng combination therapy is relatively effective in improving liver function and major complications of decompensated liver cirrhosis without adverse effects. Further clinical trials are warranted to assess the clinical effects of G-CSF for decompensated liver cirrhosis.
목차
Introduction
Patients and methods
Results
Acknowledgements
References
참고문헌 (27)
참고문헌 신청
Haagsma EB / 2001 / Increased cancer risk after liver transplantation : a population-based study / J Hepatol 34:84~91
Park HW / 2012 / De novo malignancies after liver transplantation : incidence comparison with the Korean cancer registry / Transplant Proc 44:802~805
Preston SL / 2003 / The new stem cell biology : something for everyone / Mol Pathol 56:86~96
am Esch JS 2nd / 2005 / Portal application of autologous CD133+ bone marrow cells to the liver : a novel concept to support hepatic regeneration / Stem Cells 23:463~470
Terai S / 2006 / Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy / Stem Cells 24:2292~2298
Park HW / 2012 / De novo malignancies after liver transplantation : incidence comparison with the Korean cancer registry / Transplant Proc 44:802~805
Preston SL / 2003 / The new stem cell biology : something for everyone / Mol Pathol 56:86~96
am Esch JS 2nd / 2005 / Portal application of autologous CD133+ bone marrow cells to the liver : a novel concept to support hepatic regeneration / Stem Cells 23:463~470
Terai S / 2006 / Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy / Stem Cells 24:2292~2298
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UCI(KEPA) : I410-ECN-0101-2017-519-002364988