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논문 기본 정보

자료유형
학술저널
저자정보
Kwon Jung Hyun (Precision Population Science Lab Department of Pediatrics and Adolescence Medicine Mayo Clinic Roch) Wi Chung-Il (Precision Population Science Lab Department of Pediatrics and Adolescence Medicine Mayo Clinic Roch) Seol Hee Yun (Precision Population Science Lab Department of Pediatrics and Adolescence Medicine Mayo Clinic Roch) Park Miguel (Division of Allergy and Immunology Mayo Clinic Rochester MN USA.) King Katherine (Department of Quantitative Health Sciences Mayo Clinic Rochester MN USA.) Ryu Euijung (Department of Quantitative Health Sciences Mayo Clinic Rochester MN USA.) Sohn Sunghwan (Department of Artificial Intelligence and Informatics Mayo Clinic Rochester MN USA.) Liu Hongfang (Department of Artificial Intelligence and Informatics Mayo Clinic Rochester MN USA.) Juhn Young J. (Precision Population Science Lab Department of Pediatrics and Adolescence Medicine Mayo Clinic Roch)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.13 No.5
발행연도
2021.9
수록면
697 - 718 (22page)
DOI
10.4168/aair.2021.13.5.697

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Our prior work and the work of others have demonstrated that asthma increases the risk of a broad range of both respiratory (e.g., pneumonia and pertussis) and non-respiratory (e.g., zoster and appendicitis) infectious diseases as well as inflammatory diseases (e.g., celiac disease and myocardial infarction [MI]), suggesting the systemic disease nature of asthma and its impact beyond the airways. We call these conditions asthma-associated infectious and inflammatory multimorbidities (AIMs). At present, little is known about why some people with asthma are at high-risk of AIMs, and others are not, to the extent to which controlling asthma reduces the risk of AIMs and which specific therapies mitigate the risk of AIMs. These questions represent a significant knowledge gap in asthma research and unmet needs in asthma care, because there are no guidelines addressing the identification and management of AIMs. This is a systematic review on the association of asthma with the risk of AIMs and a case study to highlight that 1) AIMs are relatively under-recognized conditions, but pose major health threats to people with asthma; 2) AIMs provide insights into immunological and clinical features of asthma as a systemic inflammatory disease beyond a solely chronic airway disease; and 3) it is time to recognize AIMs as a distinctive asthma phenotype in order to advance asthma research and improve asthma care. An improved understanding of AIMs and their underlying mechanisms will bring valuable and new perspectives improving the practice, research, and public health related to asthma.

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