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The Major Role of NF-κB in the Depth of Invasion on Acral Melanoma by Decreasing CD8+ T Cells
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논문 기본 정보

Type
Academic journal
Author
Journal
대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제52권 제3호 KCI Accredited Journals
Published
2018.1
Pages
164 - 170 (7page)

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The Major Role of NF-κB in the Depth of Invasion on Acral Melanoma by Decreasing CD8+ T Cells
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Background: The tumor microenvironment including immune surveillance affects malignant melanoma (MM) behavior. Nuclear factor κB (NF-κB) stimulates the transcription of various genes in the nucleus and plays a role in the inflammatory process and in tumorigenesis. CD8+ T cells have cytotoxic properties important in the elimination of tumors. However, inhibitory receptors on the cell surface will bind to programmed death-ligand 1 (PD-L1), causing CD8+ T cells to lose their ability to initiate an immune response. This study analyzed the association of NF-κB and PD-L1 expression levels and CD8+ T-cell counts with depth of invasion of acral MM, which may be a predictor of aggressiveness related to an increased risk of metastasis. Methods: A retrospective cross-sectional study was conducted in the Department of Anatomical Pathology, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin Hospital using 96 cases of acral melanoma. Immunohistochemical staining was performed on paraffin blocks using anti–NF-κB, –PD-L1, and –CD8 antibodies and invasion depth was measured using dotSlide-imaging software. Results: The study showed significant associations between the individual expression of NF-κB and PD-L1 and CD8+ T-cell number, with MM invasion depth. NF-κB was found to be a confounding variable of CD8+ T-cell number (p < .05), but not for PD-L1 expression (p = .154). Through multivariate analysis it was found that NF-κB had the greatest association with the depth of invasion (p < .001), whereas PD-L1 was unrelated to the depth of invasion because it depends on the number of CD8+ T cells (p = .870). Conclusions: NF-κB plays a major role in acral MM invasion, by decreasing the number of CD8+ T cells in acral MM.

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References (32)

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Oeckinghaus A / 2009 / The $NF-{\kappa}B$ family of transcription factors and its regulation / Cold Spring Harb Perspect Biol 1:a000034 google schola Bommarito A / 2011 / BRAFV600E mutation, TIMP-1 upregulation, and $NF-{\kappa}B$ activation: closing the loop on the papillary thyroid cancer trilogy / Endocr Relat Cancer 18:669~685 Crossref Yang G / 2011 / The biphasic role of $NF-{\kappa}B$ in progression and chemoresistance of ovarian cancer / Clin Cancer Res 17:2181~2194 Crossref Mao Y / 2014 / The value of tumor infiltrating lymphocytes (TILs) for predicting response to neoadjuvant chemotherapy in breast cancer: a systematic review and meta-analysis / PLoS One 9:e115103 Crossref Bogunovic D / 2009 / Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival / Proc Natl Acad Sci U S A 106:20429~20434 Crossref

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