Alteration of $CD4^+CD25^+Foxp3^+$ T cell level In Kawasaki disease

Sohn, Su-Ye; Song, Young-Wooh; Yeo, Yun-Ku; Kim, Yun-Kyung; Jang, Gi-Young; Woo, Chan-Wook; Lee, Jung-Hwa; Lee, Kwang-Chul

추천

검색

자료유형: 학술저널

저자정보: Sohn, Su-Ye (Department of Pediatrics, Korea University College of Medicine) Song, Young-Wooh (Department of Pediatrics, Korea University College of Medicine) Yeo, Yun-Ku (Department of Pediatrics, Korea University College of Medicine) Kim, Yun-Kyung (Department of Pediatrics, Korea University College of Medicine) Jang, Gi-Young (Department of Pediatrics, Korea University College of Medicine) Woo, Chan-Wook (Department of Pediatrics, Korea University College of Medicine) Lee, Jung-Hwa (Department of Pediatrics, Korea University College of Medicine) Lee, Kwang-Chul (Department of Pediatrics, Korea University College of Medicine)

저널정보: 대한소아청소년과학회 Clinical and Experimental Pediatrics Korean journal of pediatrics 제54권 제4호

발행연도: 2011.1

수록면: 157 - 162 (6page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Purpose: Exaggerated pro-inflammatory reactions during the acute phase of Kawasaki disease (KD) suggest the role of immune dysregulation in the pathogenesis of KD. We investigated the profiles of T regulatory cells and their correlation with the clinical course of KD. Methods: Peripheral blood mononuclear cells were collected from 17 KD patients during acute febrile and subacute afebrile phases. T cells expressing CD4, CD25, and Foxp3 were analyzed using flow cytometry, and the results were correlated with the clinical course of KD. Results: The percentage of circulating $CD4^+CD25^{high}Foxp3^+$ T cells among $CD4^+$ T cells was Significantly higher during the subacute afebrile phase than during the acute febrile phase ($1.10%{\pm}1.22%$ vs. $0.55%{\pm}0.53%$, P=0.049). Although levels of $CD4^+CD25^{low}Foxp3^+$ T cells and $CD4^+CD25^-Foxp3^+$ T cells were only slightly altered, the percentage of $CD4^+CD25^+Foxp3^-$ T cells among $CD4^+$ T cells was significantly lower during the subacute afebrile phase than during the acute febrile phase ($2.96%{\pm}1.95%$ vs. $5.64%{\pm}5.69%$, P=0.036). Consequently, the ratio of $CD25^{high}Foxp3^+$ T cells to $CD25^+Foxp3^-$ T cells was higher during the subacute afebrile phase than during the acute febrile phase ($0.45%{\pm}0.57%$ vs. $0.13%{\pm}0.13%$, P=0.038). Conclusion: Decreased $CD4^+CD25^{high}Foxp3^+$ T cells and/or an imbalanced ratio of $CD4^+CD25^{high}Foxp3^+$ T cells to $CD4^+CD25^+Foxp3^-$ T cells might playa role in KD development. Considering that all KD patients were treated with intravenous immunoglobulin (IVIG), recovery of $CD4^+CD25^{high}Foxp3^+$ T cells during the subacute afebrile phase could be a mechanism of IVIG.

#Kawasaki disease #Regulatory T cell #$CD25^+$ #$Foxp3^+$

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요