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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제14권 제3호
- 발행연도
- 2011.1
- 수록면
- 258 - 268 (11page)
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Purpose: Forkhead box protein 3 (FOXP3)+T cells are the major regulatory T cells controlling all aspects of the immune response. Transforming growth factor-β (TGF-β) is a suppressive cytokine which mediates the suppressive action of FOXP3+T cells. The aim of this study was to investigate the role of FOXP3+T cells, TGF-β in colonic mucosa of children with Crohn’s disease (CD).
Methods: Colonic mucosal biopsies were obtained from 10 children with CD (12∼15 years of age) and 11 control (8∼15 years of age). Frequencies of FOXP3+T, CD4+T cells and TGF-β1 expression were examined in the lamina propria (LP) and lymphoid aggregates or follicles (LA/F) by immunohistochemistry, and later evaluated by association with disease activity.
Results: In the LP of CD group, frequencies of FOXP3+T, CD4+T cells, proportion of FOXP3/CD4+T cells and TGF-β1 expression significantly increased compared to the control. In the LA/F of CD group, frequency of FOXP3+T cells, proportion of FOXP3/CD4+T cells and TGF-β1 expression significantly increased compared to the control (p＜0.05). CD4+T cells also increased compared to the control, but this finding was not significant. In the LP and LA/F of CD group, frequency of FOXP3+T cells exhibited positive correlation with CD4+T cells (p＜0.05). In the LP and LA/F of CD group, TGF-β1 expression had positive correlation with CRP, Pediatric Crohn's Disease Activity Index, and negative correlation with hematocrit and albumin (p＜0.05).
Conclusion: Increased frequency of FOXP3+T cells and TGF-β1 expression in colonic mucosa of CD can be interpreted as a compensatory increase towards achieving down-regulation of immune responses. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 258∼268)
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참고문헌 (36)
참고문헌 신청
Eastaff-Leung N / 2010 / Foxp3+ regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease / J Clin Immunol 30:80~89
Makita S / 2004 / CD4+CD25 bright T cells in human intestinal lamina propria as regulatory cells / J Immunol 173:3119~3130
Holmén N / 2006 / Functional CD4+CD25high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity / Inflamm Bowel Dis 12:447~456
Babyatsky MW / 1996 / Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease / Gastroenterology 110:975~984
Ikeda M / 2006 / Flow cytometric analysis of expression of transforming growth factor-beta and glucocorticoid-induced tumor necrosis factor receptor on CD4(+) CD25(+) T cells of patients with inflammatory bowel disease / Dig Dis Sci 51:178~184
Makita S / 2004 / CD4+CD25 bright T cells in human intestinal lamina propria as regulatory cells / J Immunol 173:3119~3130
Holmén N / 2006 / Functional CD4+CD25high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity / Inflamm Bowel Dis 12:447~456
Babyatsky MW / 1996 / Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease / Gastroenterology 110:975~984
Ikeda M / 2006 / Flow cytometric analysis of expression of transforming growth factor-beta and glucocorticoid-induced tumor necrosis factor receptor on CD4(+) CD25(+) T cells of patients with inflammatory bowel disease / Dig Dis Sci 51:178~184
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