Presence of Tumour-infiltrating FOXP3 Lymphocytes Correlates with Immature Tumour Angiogenesis in Renal Cell Carcinomas

Zhan, Hai-Lun; Gao, Xin; Zhou, Xiang-Fu; Pu, Xiao-Yong; Wang, De-Juan

추천

검색

자료유형: 학술저널

저자정보: Zhan, Hai-Lun (Department of Urology, the Third Affiliated Hospital of Sun Yat-Sen University) Gao, Xin (Department of Urology, the Third Affiliated Hospital of Sun Yat-Sen University) Zhou, Xiang-Fu (Department of Urology, the Third Affiliated Hospital of Sun Yat-Sen University) Pu, Xiao-Yong (Department of Urology, the Third Affiliated Hospital of Sun Yat-Sen University) Wang, De-Juan (Department of Urology, the Third Affiliated Hospital of Sun Yat-Sen University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제3호

발행연도: 2012.1

수록면: 867 - 872 (6page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background: $FOXP3^+$ regulatory T cells (Tregs) inhibit effector T cell functions and are implicated in tumour progression. However, together with microvessel density (MVD) they remain controversial prognostic predictors for renal cell carcinoma (RCC), and potential associations have yet to be determined. The objective of this study was to determine the prognostic significance of Tregs and MVD and their potential relationship in RCCs. Design: Paraffin-embedded tissues from 62 RCC patients were analysed using immunohistochemistry to detect $FOXP3^+$ lymphocytes, and double immunohistochemistry to detect different microvessel types in the tumour interior, rim and normal kidney tissue, and their correlation with clinicopathological characteristics. Survival analysis was also performed. Results: The presence of $FOXP3^+$ cells in the tumour interior or the rim showed no correlation with death from RCC and other pathological characteristics. Negative correlations were noted between the immature MVD in the tumour interior or the rim and tumour size, tumour stage and overall survival; however, there was no correlation with the nuclear grade or pathological type. A positive correlation between $FOXP3^+$ Tregs and immature MVD (r=0.363, P=0.014) and mature MVD (r=0.383, P=0.009) was confirmed in the tumour interior. However, there was no correlation between $FOXP3^+$ Tregs and mature MVD (r=0.281, P=0.076) or immature MVD (r=0.064, P=0.692) in the tumour rim. Conclusions: In this study, a positive correlation between the presence of $FOXP3^+$ Tregs and immature and mature MVD in RCC was confirmed, which suggests a link between suppression of immunity, tumour angiogenesis and poor prognosis.

#Renal cell carcinoma #FOXP3 #regulatory T cells #angiogenesis

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요