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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제53권 제1호
- 발행연도
- 2019.1
- 수록면
- 13 - 22 (10page)
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Background: S100A8 and S100A9 have been gaining recognition for modulating tumor growth and metastasis. This study aimed at evaluating the clinical significance of S100A8 and S100A9 in non-small cell lung cancer (NSCLC). Methods: We analyzed the relationship between S100A8 and S100A9 expressions, clinicopathological characteristics, and prognostic significance in tumor cells and peritumoral inflammatory cells. Results: The positive staining of S100A8 in tumor cells was significantly increased in male (p < .001), smoker (p = .034), surgical method other than lobectomy (p = .024), squamous cell carcinoma (SQCC) (p < .001) and higher TNM stage (p = .022) compared with female, non-smoker, lobectomy, adenocarcinoma (ADC), and lower stage. The proportion of tumor cells stained for S100A8 was related to histologic type (p < .001) and patient sex (p = .027). The proportion of inflammatory cells stained for S100A8 was correlated with patient age (p = .022), whereas the proportion of inflammatory cells stained for S100A9 was correlated with patient sex (p < .001) and smoking history (p = .031). Moreover, positive staining in tumor cells, more than 50% of the tumor cells stained and less than 30% of the inflammatory cells stained for S100A8 and S100A9 suggested a tendency towards increased survivability in SQCC but towards decreased survivability in ADC. Conclusions: S100A8 and S100A9 expressions might be potential prognostic markers in patients with NSCLC.
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참고문헌 (35)
참고문헌 신청
Young Min Jo / 2016 / Prognostic Significance of Aquaporin 5 Expression in Non-small Cell Lung Cancer / Journal of Pathology and Translational Medicine 50(2):122~128
Sang Hwa Lee / 2015 / Analysis of Mutations in Epidermal Growth Factor Receptor Gene in Korean Patients with Non-small Cell Lung Cancer: Summary of a Nationwide Survey / Journal of Pathology and Translational Medicine 49(6):481~488
Fan B / 2012 / Presence of S100A9-positive inflammatory cells in cancer tissues correlates with an early stage cancer and a better prognosis in patients with gastric cancer / BMC Cancer 12:316
Yasar O / 2017 / Significance of S100A8, S100A9 and calprotectin levels in bladder cancer / Scand J Clin Lab Invest 77:437~441
Salama I / 2008 / A review of the S100proteins in cancer / Eur J Surg Oncol 34:357~364
Sang Hwa Lee / 2015 / Analysis of Mutations in Epidermal Growth Factor Receptor Gene in Korean Patients with Non-small Cell Lung Cancer: Summary of a Nationwide Survey / Journal of Pathology and Translational Medicine 49(6):481~488
Fan B / 2012 / Presence of S100A9-positive inflammatory cells in cancer tissues correlates with an early stage cancer and a better prognosis in patients with gastric cancer / BMC Cancer 12:316
Yasar O / 2017 / Significance of S100A8, S100A9 and calprotectin levels in bladder cancer / Scand J Clin Lab Invest 77:437~441
Salama I / 2008 / A review of the S100proteins in cancer / Eur J Surg Oncol 34:357~364
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