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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 205 - 211 (7page)
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초록· 키워드
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Gingival overgrowth can cause dental occlusion and
seriously interfere with mastication, speech, and dental
hygiene. It is observed in 25 to 81 % of renal transplant
patients treated with cyclosporine A (CsA). CsA-induced
gingival overgrowth (CIGO) is caused by quantitative
alteration of the extracellular matrix components,
particularly collagen. However, the molecular mechanisms
involved in the pathogenesis of CIGO remain poorly
understood, despite intense clinical and laboratory
investigations. The aim of the present work is to identify
differentially expressed genes closely associated with CIGO.
Human gingival fibroblasts were isolated by primary
explant culture of gingival tissues from five healthy subjects
(HGFs) and two patients with the CIGO (CIGO-HGFs).
The proliferative activity of CsA-treated HGFs and CIGOHGFs
was examined using the MTT assay. The
identification of differentially expressed genes in CsAtreated
CIGO-HGF was performed by differential display
reverse transcriptase-polymerase chain reaction (RT-PCR)
followed by DNA sequencing. CsA significantly increased
the proliferation of two HGFs and two CIGO-HGFs,
whereas three HGFs were not affected. Seven genes,
including the beta subunit of prolyl 4-hydroxylase (P4HB)
and testican 1, were upregulated by CsA in a highly
proliferative CIGO-HGF. The increased P4HB and
testican-1 mRNA levels were confirmed in CsA-treated
CIGO-HGFs by semiquantitative RT-PCR. Furthermore,
CsA increased type I collagen mRNA levels and suppressed
MMP-2 mRNA levels, which are regulated by P4HB and
testican-1, respectively. These results suggest that CsA may
induce gingival overgrowth through the upregulation of
P4HB and testican-1, resulting in the accumulation of
extracellular matrix components.
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참고문헌 (20)
참고문헌 신청
Alliel PM / 1993 / Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour / European Journal of Biochemistry 214 : 347 ~ 350
Aoyagi M / 2002 / Prolyl 4-hydroxylase inhibitor is more effective for the inhibition of proliferation than for inhibition of collagen synthesis of rat hepatic satellite cell
Atilla G / 1998 / N. Cervicular fluid interleukin-1β, tumor necrosis factor-α, and interleukin-8 levels in renal transplant patients receiving cyclosporin A / Journal of Pe
Barber MT / 1992 / The effect of cyclosporin and lipopolysaccharide on fibroblasts: implications for cyclosporin-induced gingival overgrowth / Journal of Periodontology? 63 :
Bartold PM / 1989 / Regulation of human gingival fibroblast growth and synthetic activity by cyclosporin-A in vitro / Journal of Periodontal Research? 24 : 314 ~ 321
Aoyagi M / 2002 / Prolyl 4-hydroxylase inhibitor is more effective for the inhibition of proliferation than for inhibition of collagen synthesis of rat hepatic satellite cell
Atilla G / 1998 / N. Cervicular fluid interleukin-1β, tumor necrosis factor-α, and interleukin-8 levels in renal transplant patients receiving cyclosporin A / Journal of Pe
Barber MT / 1992 / The effect of cyclosporin and lipopolysaccharide on fibroblasts: implications for cyclosporin-induced gingival overgrowth / Journal of Periodontology? 63 :
Bartold PM / 1989 / Regulation of human gingival fibroblast growth and synthetic activity by cyclosporin-A in vitro / Journal of Periodontal Research? 24 : 314 ~ 321
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