지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.6
- 수록면
- 1 - 6 (6page)
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초록· 키워드
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Patients with gingival overgrowth are easily seen in dental clinics. Cyclosporin-A (CsA), a widely prescribed immunosuppressant induces gingival overgrowth in up to 35% of patients with medical history of organ transplantation. The immunosuppressant CsA can transform genetic expression of gingival fibroblasts, resulting in gingival overgrowth. Meticulous plaque control is recommended for treatment of gingival overgrowth. Substitution of the drug or surgical procedures such as gingivectomy and periodontal flaps should be considered after re-evaluation. Azithromycin is often recommended as a supplementary drug to reduce this side effect. Recent studies show that tacrolimus can be a more economic, efficient and safe substitute for CsA.
목차
Abstract
Introduction
Immunosuppressants and Calcium Channel Blockers as Inducers of Gingival Overgrowth
Mechanism of Drug-induced Alterations in Gingival Tissues
Cyclosporin Pharmacokinetics
Biofilm (Bacterial Plaque)
Predisposing Factors : Age, Hereditary Conditions
Treatment of Gingival Overgrowth
Azithromycin : For Decreasing Gingival Growth
Tacrolimus : A New Age of Immunosuppressants
Conclusion
References
참고문헌 (43)
참고문헌 신청
1. [보고서] - Korean Network for Organ Sharing / 2010 / 2010 annual report on organ sharing
2. [학술지(정기간행물)] - Britton S / 1982 / Cyclosporin A--usefulness, risks and mechanism of action / Immunol Rev 65 : 5 ~ 22
3. [학술지(정기간행물)] - Seymour RA / 1997 / Oral lesions in organ transplant patients / J Oral Pathol Med 26 : 297 ~ 304
4. [학술지(정기간행물)] - King GN / 1993 / Gingival hyperplasia in renal allograft recipients recei ving cyclosporin-A and calcium antagonists / J Clin Periodontol 20 : 286 ~ 293
5. [학술지(정기간행물)] - Thomason JM / 1993 / The prevalence and severity of cyclosporin and nifedipine-induced gingival overgrowth / J Clin Periodontol 20 : 37 ~ 40
2. [학술지(정기간행물)] - Britton S / 1982 / Cyclosporin A--usefulness, risks and mechanism of action / Immunol Rev 65 : 5 ~ 22
3. [학술지(정기간행물)] - Seymour RA / 1997 / Oral lesions in organ transplant patients / J Oral Pathol Med 26 : 297 ~ 304
4. [학술지(정기간행물)] - King GN / 1993 / Gingival hyperplasia in renal allograft recipients recei ving cyclosporin-A and calcium antagonists / J Clin Periodontol 20 : 286 ~ 293
5. [학술지(정기간행물)] - Thomason JM / 1993 / The prevalence and severity of cyclosporin and nifedipine-induced gingival overgrowth / J Clin Periodontol 20 : 37 ~ 40
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UCI(KEPA) : I410-ECN-0101-2014-510-002345786