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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 413 - 418 (6page)
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Beta-Amyloid (Aβ)-induced neuroinflammation is one of the key events in the development of neurodegenerative disease.
We previously reported that KHG21834, a benzothiazole derivative,attenuates Aβ-induced degeneration of cortical and mesencephalic neurons in vitro. In the present work, we show that KHG21834 reduces Aβ-mediated neuroinflammation in brain. In vivo intracerebroventricular infusion of KHG21834leads to decreases in the numbers of activated astrocytes and microglia and level of proinflammatory cytokines such as interleukin-1β and tumor necrosis factor-α induced by Aβ in the hippocampus. This suppression of neuroinflammation is associated with decreased neuron loss, restoration of synaptic dysfunction biomarkers in the hippocampus to control level, and diminished amyloid deposition. These results may suggest the potential therapeutic efficacy of KHG21834 for the treatment of Aβ-mediated neuroinflammation.
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참고문헌 (42)
참고문헌 신청
Heiser, V. / 2002 / Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay / Proc. Natl. Acad. Sci. U.S.A. :16400~16406
Ishiyama, T. / 2004 / Riluzole slows the progression of neuromuscular dysfunction in the wobbler mouse motor neuron disease / Brain Res. 1019:226~236
Mortimer, C. G. / 2006 / Antitumor Benzothiazoles. 26.1 2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines / J. Med. Chem. 49:179~185
Pietrancosta, N. / 2006 / Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism / J. Med. Chem. 49:3645~3652
Mathis, C. A. / 2002 / A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain / Bioorg. Med. Chem. Lett. 12:295~298
Ishiyama, T. / 2004 / Riluzole slows the progression of neuromuscular dysfunction in the wobbler mouse motor neuron disease / Brain Res. 1019:226~236
Mortimer, C. G. / 2006 / Antitumor Benzothiazoles. 26.1 2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines / J. Med. Chem. 49:179~185
Pietrancosta, N. / 2006 / Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism / J. Med. Chem. 49:3645~3652
Mathis, C. A. / 2002 / A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain / Bioorg. Med. Chem. Lett. 12:295~298
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