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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 687 - 692 (6page)
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We recently reported the anti-inflammatory effects of 3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride (KHG26792) on the ATP-induced activation of the NFAT and MAPK pathways through the P2X7 receptor in microglia. To further investigate the underlying mechanism of KHG26792, we studied its protective effects on hypoxia-induced toxicity in microglia. The administration of KHG26792 significantly reduced the hypoxia-induced expression and activity of caspase-3 in BV-2 microglial cells. KHG26792 also reduced hypoxia-induced inducible nitric oxide synthase protein expression, which correlated with reduced nitric oxide accumulation. In addition, KHG26792 attenuated hypoxiainduced protein nitration, reactive oxygen species production, and NADPH oxidase activity. These effects were accompanied by the suppression of hypoxia-induced protein expression of hypoxia-inducible factor 1-alpha and NADPH oxidase-2.
Although the clinical relevance of our findings remains to be determined, these data results suggest that KHG26792 prevents hypoxia-induced toxicity by suppressing microglial activation.
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참고문헌 (23)
참고문헌 신청
Shi H / 2013 / Kruppel-like factor 2protects against ischemic stroke by regulating endothelial blood brain barrier function / Am J Physiol Heart Circ Physiol 304:H796~H805
Zhang Q / 2015 / Resveratrol attenuates hypoxia-induced neurotoxicity through inhibiting microglial activation / Int Immunopharmacol 28:578~587
Chamorro A / 2006 / The harms and benefits of inflammatory and immune responses in vascular disease / Stroke 37:291~293
Lowe JT / 2012 / Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries / J Org Chem 77:7187~7211
Mnich SJ / 2010 / Anti-inflammatory properties of CB1-receptor antagonist involves beta2 adrenoceptors / J Pharmacol Exp Ther 333:445~453
Zhang Q / 2015 / Resveratrol attenuates hypoxia-induced neurotoxicity through inhibiting microglial activation / Int Immunopharmacol 28:578~587
Chamorro A / 2006 / The harms and benefits of inflammatory and immune responses in vascular disease / Stroke 37:291~293
Lowe JT / 2012 / Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries / J Org Chem 77:7187~7211
Mnich SJ / 2010 / Anti-inflammatory properties of CB1-receptor antagonist involves beta2 adrenoceptors / J Pharmacol Exp Ther 333:445~453
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