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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 28 - 34 (7page)
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Sphingolipids are ubiquitous building blocks of eukaryotic cell membranes that function as signaling molecules for regulating a diverse range of cellular processes, including cell proliferation, growth, survival, immune-cell trafficking, vascular and epithelial integrity, and inflammation. Recently, several studies have highlighted the pivotal role of sphingolipids in neuroinflammatory regulation. Sphingolipids have multiple functions, including induction of the expression of various inflammatory mediators and regulation of neuroinflammation by directly effecting the cells of the central nervous system. Accumulating evidence points to sphingolipid engagement in neuroinflammatory disorders, including Alzheimer’s and Parkinson’s diseases. Abnormal sphingolipid alterations, which involves an increase in ceramide and a decrease in sphingosine kinase, are observed during neuroinflammatory disease. These trends are observed early during disease development, and thus highlight the potential of sphingolipids as a new therapeutic and diagnostic target for neuroinflammatory diseases.
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참고문헌 (62)
참고문헌 신청
Maceyka M / 2014 / Sphingolipid metabolites in inflammatory disease / Nature 510:58~67
Merrill AH Jr / 2011 / Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics / Chem Rev 111:6387~6422
Hannun YA / 2018 / Sphingolipids and their metabolism in physiology and disease / Nat Rev Mol Cell Biol 19:175~191
Nixon GF / 2009 / Sphingolipids in inflammation : pathological implications and potential therapeutic targets / Br J Pharmacol 158:982~993
Chitnis T / 2017 / CNS inflammation and neurodegeneration / J Clin Invest 127:3577~3587
Merrill AH Jr / 2011 / Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics / Chem Rev 111:6387~6422
Hannun YA / 2018 / Sphingolipids and their metabolism in physiology and disease / Nat Rev Mol Cell Biol 19:175~191
Nixon GF / 2009 / Sphingolipids in inflammation : pathological implications and potential therapeutic targets / Br J Pharmacol 158:982~993
Chitnis T / 2017 / CNS inflammation and neurodegeneration / J Clin Invest 127:3577~3587
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