지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 458 - 463 (6page)
이용수
초록· 키워드
오류제보하기
We investigated the mechanisms involved in KHG26377 regulation of glutamate dehydrogenase (GDH) activity, focusing on the roles of SIRT4 and SIRT3. Intraperitoneal injection of mice with KHG26377 reduced GDH activity with concomitant repression of glucose-induced insulin secretion. Consistent with their known functions, SIRT4 ribosylated GDH and reduced its activity, and SIRT3 deacetylated GDH, increasing its activity.
However, KHG26377 did not affect SIRT4-mediated ADP-ribosylation/inhibition or SIRT3-mediated deacetylation/activation of GDH. KHG26377 had no effect on SIRT4 protein levels,and did not alter total GDH, acetylated GDH, or SIRT3 protein levels in pancreatic mitochondrial lysates. These results suggest that the mechanism by which KHG26377 inhibits GDH activity and insulin secretion does not involve ADP-ribosylation of GDH by SIRT4 or deacetylation of GDH by SIRT3.
[BMB Reports 2012; 45(8): 458-463]
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Ahuja, N. / 2007 / Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase / J. Biol. Chem. 282 : 33583 ~ 33592
Anno, T. / 2004 / Overexpression of constitutively activated glutamatedehydrogenase induces insulin secretion through enhancedglutamate oxidation / Am. J. Physiol. Endocrinol
Bryla, J. / 1994 / Regulation of the glutamate dehydrogenase activity in rat islets of Langerhans and its consequence on insulin release / Metabolism 43 : 1187 ~ 1195
Carobbio, S. / 2004 / Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets / Diabetologia 47 : 266 ~ 276
Carobbio, S. / 2009 / Deletion of glutamate dehydrogenase in β-Cells abolishes part of the insulin secretory response not required for glucose homeostasis / J. Biol. Chem. 2
Anno, T. / 2004 / Overexpression of constitutively activated glutamatedehydrogenase induces insulin secretion through enhancedglutamate oxidation / Am. J. Physiol. Endocrinol
Bryla, J. / 1994 / Regulation of the glutamate dehydrogenase activity in rat islets of Langerhans and its consequence on insulin release / Metabolism 43 : 1187 ~ 1195
Carobbio, S. / 2004 / Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets / Diabetologia 47 : 266 ~ 276
Carobbio, S. / 2009 / Deletion of glutamate dehydrogenase in β-Cells abolishes part of the insulin secretory response not required for glucose homeostasis / J. Biol. Chem. 2
이 논문의 저자 정보
최근 본 자료
댓글(0)
0