지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 324 - 330 (7page)
이용수
초록· 키워드
오류제보하기
Adiponectin, one of the most abundant plasma protein produced in adipose tissue, has been shown to be decreased in the plasma of patients with various types of cancer suggesting that adiponectin may be involved in the pathogenesis of tumor progression. In addition, studies have shown that this adipokine exhibit a suppressive effect on different types of malignancy. However, the role of adiponectin in tumor progression or tumor immunity remains unknown. In this study, we assessed the effect of adiponectin on murine breast cancer progression. We implanted murine breast cancer cells (EMT6) breast cancer cells subcutaneously into the tight flank of syngeneic mice. Local administration of adiponectin to tumor tissue decreased tumor mass in a dose-dependent manner. Since intratumoral injection of lipopolysaccharide (LPS), the major component of endotoxin, is known to inhibit tumor growth, the observed anti-tumor effect of the recombinant adiponectin might be attributable to the contamination of low amounts of bacterial endotoxin. We showed that intratumoral injection of low dose LPS failed to inhibit tumor growth and heat inactivation or protease treatment completely abrogated the cytokine’s ability to induce IL-12p35 expression in mouse bone marrow-derived dendritic cells clearly demonstrating that the observed anti-tumor effect of recombinant adiponectin is not due to LPS contamination. Our data clearly suggest that adiponectin exerts anti-tumor effects in the breast cancer model of mice via reduction of tumor-induced hematopoiesis and intratumoral injection of adiponectin may be a new strategy for the treatment of established breast cancer.
목차
등록된 정보가 없습니다.
참고문헌 (56)
참고문헌 신청
Pajvani UB / 2003 / Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. / J Biol Chem 278:9073~9085
Suzuki S / 2007 / The oligomeric structure of high molecular weight adiponectin / FEBS Lett 581:809~814
Waki H / 2005 / Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1 / Endocrinology 146:790~796
Matsubara M / 2002 / Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women / Eur J Endocrinol 147:173~180
Menzaghi C / 2002 / A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome / Diabetes 51:2306~2312
Suzuki S / 2007 / The oligomeric structure of high molecular weight adiponectin / FEBS Lett 581:809~814
Waki H / 2005 / Generation of globular fragment of adiponectin by leukocyte elastase secreted by monocytic cell line THP-1 / Endocrinology 146:790~796
Matsubara M / 2002 / Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women / Eur J Endocrinol 147:173~180
Menzaghi C / 2002 / A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome / Diabetes 51:2306~2312
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Adiponectin에 의한 유선상피세포의 글루코스 흡수 및 성장조절작용
동물자원연구
2015 .01
-
S6K1 controls adiponectin expression by inducing a transcriptional switch: BMAL1-to-EZH2
Experimental and Molecular Medicine
2022 .03
-
Texture Analysis for Classifying Normal Tissue, Benign and Malignant Tumors from Breast Ultrasound Image
Journal of information and communication convergence engineering
2022 .03
-
Adrenergic receptor β2 activation by stress promotes breast cancer progression through macrophages M2 polarization in tumor microenvironment
BMB Reports
2015 .01
-
Rebuilding the microenvironment of primary tumors in humans: a focus on stroma
Experimental and Molecular Medicine
2024 .03
-
Tumor microenvironment and radioresistance
Experimental and Molecular Medicine
2021 .06
-
A review on three dimensional scaffolds for tumor engineering
Biomaterials and Biomechanics in Bioengineering
2016 .01
-
A new aspect of an old friend: the beneficial effect of metformin on anti-tumor immunity
BMB Reports
2020 .01
-
Engineering of vascularized 3D cancer on a chip modeling for drug delivery
대한기계학회 춘추학술대회
2021 .04
-
형태학적 연산과 뇌종양 평균 크기를 이용한 감마나이프 치료 범위 자동 검출 알고리
멀티미디어학회논문지
2015 .10
-
T Cell-mimicking Nanoparticles for Cancer Immunotherapy
한국고분자학회 학술대회 연구논문 초록집
2021 .04
-
Studying Adipose Tissue in the Breast Tumor Microenvironment In Vitro: Progress and Opportunities
조직공학과 재생의학
2020 .01
-
Engineering of tumor microenvironment on a chip for evaluating combination immunotherapy
대한기계학회 춘추학술대회
2021 .04
-
Nanocomplex-Mediated in vivo CAR-M1 Macrophage Therapy for Solid Tumors
한국고분자학회 학술대회 연구논문 초록집
2021 .10
-
Interactions between tumor-derived proteins and Toll-like receptors
Experimental and Molecular Medicine
2020 .12
-
Effects of a Human Originated Adiponectin Peptide on Lipogenesis of an Immortalized Human Sebocytes
한국생물공학회 학술대회
2015 .10
-
Development of Tumor Microenvironment-Modulating Nanoparticles for Improved Anti-Tumor Efficacy of Immunotherapy
한국고분자학회 학술대회 연구논문 초록집
2022 .04
-
A Prototype System for Early-Stage Breast Cancer Detection
Journal of Electromagnetic Engineering And Science
2015 .07
-
Common plasma protein marker LCAT in aggressive human breast cancer and canine mammary tumor
BMB Reports
2020 .01
-
Emerging role of RUNX3 in the regulation of tumor microenvironment
BMB Reports
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0