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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 174 - 181 (8page)
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초록· 키워드
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A number of genes have been therapeutically targeted to relieve cancer, but cancer relapse is still a growing issue. The concept that the surrounding tumor environment is critical for the progression of cancer may foster an answer to the issue of cancer malignancy. Runt domain transcription factors (RUNX1, 2, and 3) are evolutionarily conserved and have been intensively studied for their roles in normal development and pathological conditions. During tumor growth, a hypoxic microenvironment and infiltration of the tumor by immune cells are common phenomena. In this review, we briefly introduce the consequences of hypoxia and immune cell infiltration into the tumor microenvironment with a focus on RUNX3 as a critical regulator. Furthermore, based on our current knowledge of the functional role of RUNX3 in hypoxia and immune cell maintenance, a probable therapeutic intervention is suggested for the effective management of tumor growth and malignancy.
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참고문헌 (96)
참고문헌 신청
Klemm F / 2015 / Microenvironmental regulation of therapeutic response in cancer / Cell Biol 25:198~213
Balkwill FR / 2012 / The tumor microenvironment at a glance / J Cell Sci 125:5591~5596
Hockel M / 2001 / Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects / J Natl Cancer Inst 93:266~276
Ito Y / 1999 / Molecular basis of tissue-specific gene expression mediated by the runt domain transcription factor PEBP2/CBF / Genes Cells 4:685~696
Ito Y / 2008 / RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes / Adv Cancer Res 99:33~76
Balkwill FR / 2012 / The tumor microenvironment at a glance / J Cell Sci 125:5591~5596
Hockel M / 2001 / Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects / J Natl Cancer Inst 93:266~276
Ito Y / 1999 / Molecular basis of tissue-specific gene expression mediated by the runt domain transcription factor PEBP2/CBF / Genes Cells 4:685~696
Ito Y / 2008 / RUNX genes in development and cancer: regulation of viral gene expression and the discovery of RUNX family genes / Adv Cancer Res 99:33~76
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