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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제21권 제2호
- 발행연도
- 2018.1
- 수록면
- 111 - 117 (7page)
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Purpose: The prevalence of obesity has significantly increased among children and adolescents worldwide and is becoming an important health care problem in parallel with the increased prevalence of obesity pediatric non-alco-holic fatty liver disease. Betatrophin is a newly define hormone that is commonly secreted by liver and plays role in glucose tolerance. This study aimed to investigate the relationship between serum betatrophin levels and non-alco-holic fatty liver disease in obese children.Methods: The study included 40 obese children with a body mass index (BMI) above 95th centile, and 35 non-obese subjects with a BMI 3-85th centile, whose age and gender were similar to those of the patient group. For the evaluation of metabolic parameters fasting serum glucose, insulin, alanine aminotransferase, aspartate aminotransferase, lipid profile and serum betatrophin levels were measured. Total cholesterol: high-density lipoprotein cholesterol and low-density lipoprotein cholesterol: high-density lipoprotein cholesterol ratios were calculated as “atherogenicindices.”Results: Serum betatrophin levels of the obese subjects were similar to that of non-obese subjects (p=0.90). Betatrophin levels were not correlated with the metabolic parameters.Conclusion: In the present study, levels of betatrophin are not different between obese and insulin resistant children and non-obese subjects, and they are not correlated with atherogenic indices. To elucidate the exact role of beta-trophin in obesity, further studies are required to identify the betatrophin receptor and/or other possible cofactors.
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참고문헌 (25)
참고문헌 신청
Schwimmer JB / 2006 / Prevalence of fatty liver in children and adolescents / Pediatrics 118:1388~1393
Takahashi Y / 2010 / Pediatric nonalcoholic fatty liver disease: overview with emphasis on histology / World J Gastroenterol 16:5280~5285
Wong RJ / 2014 / Obesity and non-alcoholic fatty liver disease: disparate associations among Asian populations / World J Hepatol 6:263~273
Tominaga K / 1995 / Prevalence of fatty liver in Japanese children and relationship to obesity. An epidemiological ultrasonographic survey / Dig Dis Sci 40:2002~2009
Liu L / 2014 / Roles of chronic low-grade inflammation in the development of ectopic fat deposition / Mediators Inflamm
Takahashi Y / 2010 / Pediatric nonalcoholic fatty liver disease: overview with emphasis on histology / World J Gastroenterol 16:5280~5285
Wong RJ / 2014 / Obesity and non-alcoholic fatty liver disease: disparate associations among Asian populations / World J Hepatol 6:263~273
Tominaga K / 1995 / Prevalence of fatty liver in Japanese children and relationship to obesity. An epidemiological ultrasonographic survey / Dig Dis Sci 40:2002~2009
Liu L / 2014 / Roles of chronic low-grade inflammation in the development of ectopic fat deposition / Mediators Inflamm
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