지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 115 - 119 (5page)
이용수
초록· 키워드
오류제보하기
Betatrophin is a newly characterized circulating hormone that is produced in tissuessuch as adipose tissue and liver and stimulates pancreatic beta-cell proliferation. Thepurpose of the current study was to examine circulating betatrophin levels in Iranianpatients with type 2 diabetes mellitus (T2DM) and in normal controls. Seventy-five subjectswere enrolled in this case-control study in the following two groups: T2DM patients(n=40) and a group of age-, sex-, and BMI-matched normal control subjects (n=35). Circulating betatrophin concentrations as well as the blood lipid profile, body mass index(BMI), fasting blood sugar (FBS), glycated hemoglobin (HbA1c), and insulin resistancewere determined. Circulating betatrophin levels were significantly higher in patientswith T2DM than in the normal subjects (4.79±1.53 ng/mL vs. 2.79±1.11 ng/mLrespectively; p=0.001). Serum triacylglycerol and total cholesterol were also significantlyhigher in patients with T2DM than in the control group. In the patients withT2DM, serum betatrophin was positively correlated with age, FBS, TG, total cholesterol,and HbA1c. The results of this initial study in Iran have shown that circulating betatrophinlevels are significantly increased in Iranian patients with T2DM comparedwith a control group. Additionally, it is postulated that betatrophin as a novel hormonemay be involved in the generation of an atherogenic lipid profile.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Tuomi T. / 2014 / The many faces of diabetes : a disease with increasing heterogeneity / Lancet 383:1084~1094
Seymour PA. / 2013 / Bulking up on beta cells / N Engl J Med 369:777~779
Yi P. / 2013 / Betatrophin : a hormone that controls pancreatic cell proliferation / Cell 153:747~758
Kulkarni RN. / 2012 / Human -cell proliferation and intracellular signaling : driving in the dark without a road map / Diabetes 61:2205~2213
El Ouaamari A. / 2013 / Liver-derived systemic factors drive cell hyperplasia in insulin-resistant states / Cell Rep 3:401~410
Seymour PA. / 2013 / Bulking up on beta cells / N Engl J Med 369:777~779
Yi P. / 2013 / Betatrophin : a hormone that controls pancreatic cell proliferation / Cell 153:747~758
Kulkarni RN. / 2012 / Human -cell proliferation and intracellular signaling : driving in the dark without a road map / Diabetes 61:2205~2213
El Ouaamari A. / 2013 / Liver-derived systemic factors drive cell hyperplasia in insulin-resistant states / Cell Rep 3:401~410
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Serum Betatrophin Concentrations and the Risk of Incident Diabetes: A Nested Case-Control Study from Chungju Metabolic Disease Cohort
Diabetes and Metabolism Journal
2018 .01
-
Investigation of Blood Betatrophin Levels in Obese Children with Non-Alcoholic Fatty Liver Disease
Pediatric Gastroenterology, Hepatology & Nutrition
2018 .01
-
Follicular fluid cerebellin and betatrophin regulate the metabolic functions of growing follicles in polycystic ovary syndrome
Clinical and experimental reproductive medicine : CERM
2017 .01
-
Clinical and Laboratory Characteristics of Childhood Diabetes Mellitus: A Single-Center Study from 2000 to 2013
전남의대학술지
2016 .01
-
Long-term prognosis and clinical characteristics of patients with newly diagnosed diabetes mellitus detected after the first acute myocardial infarction: From the KAMIR-NIH registry
Korean Circulation Journal
2018 .01
-
The Impact of IT-based Self-management Service for Type 2 Diabetes Mellitus Patients in a Community
보건의료산업학회지
2021 .09
-
Sex Difference in the Effect of Body Mass Index and Stress on High-Risk Diabetes Mellitus in Korean Adults
기초간호자연과학회지
2019 .01
-
Incidence trends and associated factors of diabetes mellitus in Korean children and adolescents: a retrospective cohort study in Busan and Gyeongnam
Annals of Pediatirc Endocrinology & Metabolism
2015 .01
-
Insulin Fact Sheet in Type 1 and 2 Diabetes Mellitus and Trends of Antidiabetic Medication Use in Insulin Users with Type 2 Diabetes Mellitus: 2002 to 2019
Diabetes and Metabolism Journal
2023 .03
-
The changes of subtypes in pediatric diabetes and their clinical and laboratory characteristics over the last 20 years
Annals of Pediatirc Endocrinology & Metabolism
2016 .01
-
Impacts of circulating cytokine levels and gene polymorphism predisposition on type 1 diabetes mellitus
Annals of Pediatirc Endocrinology & Metabolism
2024 .08
-
Genetic aspects of type 1 diabetes
Annals of Pediatirc Endocrinology & Metabolism
2019 .01
-
소아청소년 제2형 당뇨병의 진단과 치료
대한의사협회지
2021 .01
-
Prediction of diabetes mellitus after kidney transplantation using patient-specific induced pluripotent stem cells
Kidney Research and Clinical Practice
2024 .03
-
Concentrations of trace metals in serum: Implications for type 2 diabetes mellitus and gender difference
Environmental Analysis Health and Toxicology
2025 .03
-
Characterization of Patients with Type 2 Diabetes according to Body Mass Index: Korea National Health and Nutrition Examination Survey from 2007 to 2011
Endocrinology and Metabolism
2015 .01
-
Incidence, Predictors, and Clinical Outcomes of New-Onset Diabetes Mellitus after Percutaneous Coronary Intervention with Drug-Eluting Stent
Journal of Korean Medical Science
2017 .01
-
Depression and Mortality in People with Type 2 Diabetes Mellitus, 2003 to 2013: A Nationwide Population-Based Cohort Study
Diabetes and Metabolism Journal
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0