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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 789 - 797 (9page)
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Background/Aims: Gastric cancer evolves in the pathologic mucosal milieu, and its development is characterized by both the loss of acid-secreting parietal cells and mucosal cell metaplasia, called spasmolytic polypeptide-expressing metaplasia (SPEM). Cytokines, such as interleukin (IL)-10, IL-1β, and IL-6, play a key role in gastric carcinogenesis. However, changes in the cytokine profile of SPEM have not been evaluated. Methods: To induce SPEM in mouse stomachs, C57BL/6 mice were intraperitoneally injected with tamoxifen and sacrificed at 3, 10, and 21 days after treatment. RNA-sequencing (RNA-seq) and a multiplex bead array were used to measure cytokines in the stomachs of tamoxifen-treated/control mice. Results: The administration of tamoxifen led to the rapid development and histological normalization of SPEM 3 and 10 days after administration, respectively. RNA-seq revealed that the expression of IL-10 was decreased 3 days after tamoxifen administration. The multiplex assay identified a significant decline in IL-10 levels 3 days after tamoxifen treatment (58.38±34.44 pg/mL vs 94.09±4.98 pg/mL, p=0.031), which normalized at 10 and 21 days after tamoxifen treatment. Immunofluorescence staining confirmed that IL-10 expression was markedly decreased at the time of SPEM development and subsequently returned to normal, accompanied by a reversal in histologic changes. Conclusions: IL-10 may play a pivotal role in the tamoxifen-induced acute development of gastric SPEM.
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참고문헌 (23)
참고문헌 신청
Abdiev S / 2010 / Helicobacter pylori infection and cytokine gene polymorphisms in Uzbeks / Nagoya J Med Sci 72 : 167 ~ 172
Bodger K / 1997 / Gastric mucosal secretion of interleukin-10: relations to histopathology, Helicobacter pylori status, and tumour necrosis facto
Bordi C / 1989 / Structure and function of endocrine cells in the oxyntic (acid-secreting) mucosa of human stomach / Scand J Gastroenterol Suppl 166 : 115 ~ 121
Chandanos E / 2006 / Tamoxifen exposure and risk of oesophageal and gastric adenocarcinoma: a population-based cohort study of breast cancer patients in Sweden / Br J Cancer
De Vita F / 1999 / Serum interleukin-10 levels in patients with advanced gastrointestinal malignancies / Cancer 86 : 1936 ~ 1943
Bodger K / 1997 / Gastric mucosal secretion of interleukin-10: relations to histopathology, Helicobacter pylori status, and tumour necrosis facto
Bordi C / 1989 / Structure and function of endocrine cells in the oxyntic (acid-secreting) mucosa of human stomach / Scand J Gastroenterol Suppl 166 : 115 ~ 121
Chandanos E / 2006 / Tamoxifen exposure and risk of oesophageal and gastric adenocarcinoma: a population-based cohort study of breast cancer patients in Sweden / Br J Cancer
De Vita F / 1999 / Serum interleukin-10 levels in patients with advanced gastrointestinal malignancies / Cancer 86 : 1936 ~ 1943
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