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논문 기본 정보

자료유형
학술저널
저자정보
이태구 (한국한의학연구원) 현수왕 (한국한의학연구원) 이익수 (한국한의학연구원) 박봉균 (한국한의학연구원) 김진숙 (한국한의학연구원) 김찬식 (한국한의학연구원)
저널정보
한국약용작물학회 한국약용작물학회지 한국약용작물학회지 제26권 제5호
발행연도
2018.10
수록면
382 - 390 (9page)
DOI
10.7783/KJMCS.2018.26.5.382

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Background: The plant Aster koraiensis has long been used as an ingredient in folk medicine. It has been reported that Aster koraiensis extract (AKE) prevents the progression of diabetes-induced retinopathy and nephropathy. However, although these beneficial effects of AKE on diabetes complications have been identified, the antidiabetic effects of AKE have not yet been completely investigated and quantified. In the present study, the glucose-lowering and antioxidant effects of aqueous and ethanolic AKEs were evaluated.
Methods and Results: The glucose-lowering effects of aqueous and ethanolic (30%−, 50%−, and 80%-ethanol) AKEs were investigated via α-glucosidase inhibitory assays. The mode of inhibition by AKEs on α-glucosidase was identified through kinetic analysis. The total antioxidant capacity of each of the 4 AKEs was evaluated by assessing their conversion rate of Cu<SUP>2+</SUP> to Cu+. The content of chlorogenic acid and 3,5-di-O-caffeoylquinic acid, the bioactive compounds in AKE, in each extract were analyzed by high performance liquid chromatography (HPLC). The AKEs showed potent α-glucosidase inhibitory activity with mixed inhibition mode, and significant antioxidant capacity.
Conclusions: These results of this study suggested that the AKEs tested had α-glucosidase inhibitory and antioxidant effects. Among the extracts, the 80% ethanol extract showed the most significant α-glucosidase inhibitory activity, with a half maximal inhibitory concentration (IC<SUB>50</SUB> value) of 1.65 ± 0.36㎎/㎖ and a half maximal effective concentration (EC<SUB>50</SUB> value) for its antioxidant activity of 0.42 ± 0.10㎎/㎖. It can therefore be used as a source of therapeutic agents to treat diabetes patients.

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