지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.4
- 수록면
- 183 - 187 (5page)
이용수
초록· 키워드
오류제보하기
Background: Gut microflora play a crucial role in the biotransformation of ginsenosides to compound K (CK), which may affect the pharmacological effects of ginseng. Prebiotics, such as NUTRIOSE, could enhance the formation and consequent absorption of CK through the modulation of gut microbial metabolic activities. In this study, the effect of a prebiotic fiber (NUTRIOSE) on the pharmacokinetics of ginsenoside CK, a bioactive metabolite of ginsenosides, and its mechanism of action were investigated.
Methods: Male SpragueeDawley rats were given control or NUTRIOSE-containing diets (control diet + NUTRIOSE) for 2 wk, and ginseng extract or vehicle was then orally administered. Blood samples were collected to investigate the pharmacokinetics of CK using liquid chromatographyetandem mass spectrometry. Fecal activities that metabolize ginsenoside Rb1 to CK were assayed with fecal specimens or bacteria cultures.
Results: When ginseng extract was orally administered to rats fed with 2.5%, 5%, or 10% NUTRIOSE containing diets, the maximum plasma concentration (C<SUB>max</SUB>) and area under the plasma concentration etime curve values of CK significantly increased in a NUTRIOSE content-dependent manner. NUTRIOSE intake increased glycosidase activity and CK formation in rat intestinal contents. The CK-forming activities of intestinal microbiota cultured in vitro were significantly induced by NUTRIOSE.
Conclusion: These results show that prebiotic diets, such as NUTRIOSE, may promote the metabolic conversion of ginsenosides to CK and the subsequent absorption of CK in the gastrointestinal tract and may potentiate the pharmacological effects of ginseng.
Methods: Male SpragueeDawley rats were given control or NUTRIOSE-containing diets (control diet + NUTRIOSE) for 2 wk, and ginseng extract or vehicle was then orally administered. Blood samples were collected to investigate the pharmacokinetics of CK using liquid chromatographyetandem mass spectrometry. Fecal activities that metabolize ginsenoside Rb1 to CK were assayed with fecal specimens or bacteria cultures.
Results: When ginseng extract was orally administered to rats fed with 2.5%, 5%, or 10% NUTRIOSE containing diets, the maximum plasma concentration (C<SUB>max</SUB>) and area under the plasma concentration etime curve values of CK significantly increased in a NUTRIOSE content-dependent manner. NUTRIOSE intake increased glycosidase activity and CK formation in rat intestinal contents. The CK-forming activities of intestinal microbiota cultured in vitro were significantly induced by NUTRIOSE.
Conclusion: These results show that prebiotic diets, such as NUTRIOSE, may promote the metabolic conversion of ginsenosides to CK and the subsequent absorption of CK in the gastrointestinal tract and may potentiate the pharmacological effects of ginseng.
목차
abstract
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (27)
참고문헌 신청
1. [학술지(정기간행물)] - 김동현 / 2012 / Chemical Diversity of Panax ginseng, Panax quinquifolium, and Panax notoginseng / Journal of Ginseng Research 36 (1) : 1 ~ 15
2. [학술지(정기간행물)] - Joh E-H / 2011 / Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation d the key step of inflammation / Biochem Pharmacol 82 : 278 ~ 286
3. [학술지(정기간행물)] - Choo M-K / 2008 / A ginseng saponin metabolite suppresses tumor necrosis factor-a-promoted metastasis by suppressing nuclear factor-kB signaling in murine colon cancer cells / Oncol Rep 19 : 595 ~ 600
4. [학술지(정기간행물)] - Wakabayashi C / 1998 / An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells / Biochem Biophys Res Commun 246 : 725 ~ 730
5. [학술지(정기간행물)] - Shin Y-W / 2005 / Antipruritic effect of ginsenoside Rb1 and compound K in scratching behavior mouse models / J Pharmacol Sci 99 : 83 ~ 88
2. [학술지(정기간행물)] - Joh E-H / 2011 / Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation d the key step of inflammation / Biochem Pharmacol 82 : 278 ~ 286
3. [학술지(정기간행물)] - Choo M-K / 2008 / A ginseng saponin metabolite suppresses tumor necrosis factor-a-promoted metastasis by suppressing nuclear factor-kB signaling in murine colon cancer cells / Oncol Rep 19 : 595 ~ 600
4. [학술지(정기간행물)] - Wakabayashi C / 1998 / An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells / Biochem Biophys Res Commun 246 : 725 ~ 730
5. [학술지(정기간행물)] - Shin Y-W / 2005 / Antipruritic effect of ginsenoside Rb1 and compound K in scratching behavior mouse models / J Pharmacol Sci 99 : 83 ~ 88
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UCI(KEPA) : I410-ECN-0101-2018-524-001597737