Genetic Diversity and Natural Selection in 42 kDa Region of Plasmodium vivax Merozoite Surface Protein-1 from China-Myanmar Endemic Border

Xia Zhou; Ernest Tambo; Jing Su; Qiang Fang; Wei Ruan; Jun-Hu Chen; Ming-Bo Yin; Xiao-Nong Zhou

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자료유형: 학술저널

저자정보: Xia Zhou (Medical College of Soochow University) Ernest Tambo (Ministry of Health) Jing Su (Fudan University) Qiang Fang (Bengbu Medical College) Wei Ruan (Zhejiang Provincial Center for Disease Control and Prevention) Jun-Hu Chen (Ministry of Health) Ming-Bo Yin (Fudan University) Xiao-Nong Zhou (Ministry of Health)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.55 No.5

발행연도: 2017.10

수록면: 473 - 480 (8page)

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Plasmodium vivax merozoite surface protein-1 (PvMSP1) gene codes for a major malaria vaccine candidate antigen. However, its polymorphic nature represents an obstacle to the design of a protective vaccine. In this study, we analyzed the genetic polymorphism and natural selection of the C-terminal 42 kDa fragment within PvMSP1 gene (Pv MSP142) from 77 P. vivax isolates, collected from imported cases of China-Myanmar border (CMB) areas in Yunnan province and the inland cases from Anhui, Yunnan, and Zhejiang province in China during 2009-2012. Totally, 41 haplotypes were identified and 30 of them were new haplotypes. The differences between the rates of non-synonymous and synonymous mutations suggest that PvMSP142 has evolved under natural selection, and a high selective pressure preferentially acted on regions identified of PvMSP133. Our results also demonstrated that PvMSP142 of P. vivax isolates collected on China-Myanmar border areas display higher genetic polymorphisms than those collected from inland of China. Such results have significant implications for understanding the dynamic of the P. vivax population and may be useful information towards China malaria elimination campaign strategies.

#Plasmodium vivax #merozoite surface protein-1 #genetic polymorphism #natural selection #Myanmar #China

참고문헌 (34)

참고문헌 신청

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