지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.2
- 수록면
- 43 - 49 (7page)
이용수
초록· 키워드
오류제보하기
The aim of the study was to explore the possible molecular markers of chloroquine resistance in Plasmodium vivax isolates in Thailand. A total of 30 P. vivax isolates were collected from a malaria endemic area along the Thai-Myanmar border in Mae Sot district of Thailand. Dried blood spot samples were collected for analysis of Pvmdr1 and Pvcrt-opolymorphisms. Blood samples (100 μl) were collected by finger-prick for in vitro chloroquine susceptibility testing by schizont maturation inhibition assay. Based on the cut-off IC<SUB>50</SUB> of 100 nM, 19 (63.3%) isolates were classified as chloroquine resistant P. vivax isolates. Seven non-synonymous mutations and 2 synonymous were identified in Pvmdr1 gene. Y976F and F1076L mutations were detected in 7 (23.3%) and 16 isolates (53.3%), respectively. Analysis of Pvcrt-o gene revealed that all isolates were wild-type. Our results suggest that chloroquine resistance gene is now spreading in this area. Monitoring of chloroquine resistant molecular markers provide a useful tool for future control of P. vivax malaria.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (22)
참고문헌 신청
World Health Organization / 2001 / The use of antimalarial drugs. Report of a WHO informal consultation
Rieckmann KH / 1989 / Plasmodium vivax resistance to chloroquine? / Lancet 2:1183~1184
Baird JK / 1991 / Resistance to chloroquine by Plasmodium vivax in Irian Jaya, Indonesia / Am J Trop Med Hyg 44:547~552
Marlar-Than / 1995 / Development of resistance to chloroquine by Plasmodium vivax in Myanmar / Trans R Soc Trop Med Hyg 89:307~308
Baird JK / 1996 / Survey of resistance to chloroquine by Plasmodium vivax in Indonesia / Trans R Soc Trop Med Hyg 90:409~411
Rieckmann KH / 1989 / Plasmodium vivax resistance to chloroquine? / Lancet 2:1183~1184
Baird JK / 1991 / Resistance to chloroquine by Plasmodium vivax in Irian Jaya, Indonesia / Am J Trop Med Hyg 44:547~552
Marlar-Than / 1995 / Development of resistance to chloroquine by Plasmodium vivax in Myanmar / Trans R Soc Trop Med Hyg 89:307~308
Baird JK / 1996 / Survey of resistance to chloroquine by Plasmodium vivax in Indonesia / Trans R Soc Trop Med Hyg 90:409~411
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Population Genetics of Plasmodium vivax in Four High Malaria Endemic Areas in Thailand
Parasites, Hosts and Diseases
2017 .10
-
Genetic Diversity of Plasmodium vivax Causing Epidemic Malaria in the Republic of Korea
Parasites, Hosts and Diseases
2018 .12
-
Epidemiological Characteristics of Re-emerging Vivax Malaria in the Republic of Korea (1993-2017)
Parasites, Hosts and Diseases
2018 .12
-
History and Current Status of Malaria in Korea
Infection and Chemotherapy
2020 .01
-
An Epidemiological Analysis of 28 Vivax Malaria Cases in Gimpo-si, Korea, 2020
Parasites, Hosts and Diseases
2021 .10
-
Therapeutic Assessment of Primaquine for Radical Cure of Plasmodium vivax Malaria at Primary and Tertiary Care Centres in Southwestern India
Parasites, Hosts and Diseases
2016 .12
-
Awareness and Opinions of Inhabitants on Vivax Malaria in Two Endemic Areas, Gyeonggi-do, Korea
Parasites, Hosts and Diseases
2021 .10
-
Genetic Diversity and Natural Selection in 42 kDa Region of Plasmodium vivax Merozoite Surface Protein-1 from China-Myanmar Endemic Border
Parasites, Hosts and Diseases
2017 .10
-
Monitoring antimalarial drug-resistance markers in Somalia
Parasites, Hosts and Diseases
2023 .02
-
Antitumor Activity of Chloroquine in Combination with Cisplatin in Human Gastric Cancer Xenografts
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
The Importance of Proper History Taking: Asking a Fever Pattern in Patients with Vivax Malaria
Journal of Korean Medical Science
2020 .01
-
Neuroprotective effects of chloroquine on neurological scores, blood-brain barrier permeability, and brain edema after traumatic brain injury in male rats
Journal of Neurocritical Care
2023 .06
-
Development of Monoclonal Antibodies for Diagnosis of Plasmodium vivax
Parasites, Hosts and Diseases
2017 .12
-
Surveillance on the Vivax Malaria in Endemic Areas in the Republic of Korea Based on Molecular and Serological Analyses
Parasites, Hosts and Diseases
2020 .12
-
PCR-RFLP for Rapid Subtyping of Plasmodium vivax Korean Isolates
Parasites, Hosts and Diseases
2017 .04
-
Chloroquine Exerts Anti-metastatic Activities Under Hypoxic Conditions in Cholangiocarcinoma Cells
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Serial follow-up of malaria-induced splenic infarction: A case report
Annals of Hepato-Biliary-Pancreatic Surgery
2020 .05
-
An Alternative Method for Extracting Plasmodium DNA from EDTA Whole Blood for Malaria Diagnosis
Parasites, Hosts and Diseases
2018 .02
-
Characteristics of Imported Malaria and Species of Plasmodium Involved in Shandong Province, China (2012-2014)
Parasites, Hosts and Diseases
2016 .08
-
Recent Spatial and Temporal Trends of Malaria in Korea
Parasites, Hosts and Diseases
2021 .12
이 논문의 저자 정보
이 논문과 함께 이용한 논문
송이버섯 추출액의 항균력 확인과 저염젓갈 생산에 적용 가능성
김진성
,
박재범
,
장승원
외 4명
KSBB Journal
2015
.10
MALDI-MS 기반 당단백질 당쇄의 정량분석 기술 개발 연구 동향
김경진
,
김윤우
,
황철환
외 3명
KSBB Journal
2015
.10
Involvement of PI3K/AKT and MAPK Pathways for TNF-α Production in SiHa Cervical Mucosal Epithelial Cells Infected with Trichomonas vaginalis
Jung-Bo Yang
,
Juan-Hua Quan
,
Ye-Eun Kim
외 6명
Parasites, Hosts and Diseases
2015
.08
LPS로 유도된 RAW264.7 Cell과 마우스모델에 대한 잘피 에탄올 추출물의 항염증 효과
김민지
,
배난영
,
김꽃봉우리
외 4명
KSBB Journal
2015
.08
Production of Liquiritigenin with Cell-based Biotransformation and Its Anti-Aging Activity
Hye Jin Hwang
,
Sang Chul Jeong
,
Jong Pil Pa
외 1명
KSBB Journal
2015
.08
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2016-513-001133909