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논문 기본 정보

자료유형
학술저널
저자정보
Sungim Choi (Dongguk University Ilsan Hospital) Heun Choi (National Health Insurance Service Ilsan Hospital) Seong Yeon Park (Dongguk University Ilsan Hospital) Yee Gyung Kwak (Inje University Ilsan Paik Hospital) Je Eun Song (Inje University Ilsan Paik Hospital) So Youn Shin (Catholic Kwandong University) Ji Hyeon Baek (Inha University School of Medicine) Hyun-IL Shin (Korea Disease Control and Prevention Agency) Hong Sang Oh (Armed Forces Capital Hospital) Yong Chan Kim (Yonsei University College of Medicine) Joon-Sup Yeom (Yonsei University College of Medicine) Jin-Hee Han (Kangwon National University) Min Jae Kim (University of Ulsan College of Medicine)
저널정보
대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.60 No.1
발행연도
2022.2
수록면
39 - 43 (5page)

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Plasmodium vivax exhibits dormant liver-stage parasites, called hypnozoites, which can cause relapse of malaria. The only drug currently used for eliminating hypnozoites is primaquine. The antimalarial properties of primaquine are dependent on the production of oxidized metabolites by the cytochrome P450 isoenzyme 2D6 (CYP2D6). Reduced primaquine metabolism may be related to P. vivax relapses. We describe a case of 4 episodes of recurrence of vivax malaria in a patient with decreased CYP2D6 function. The patient was 52-year-old male with body weight of 52 kg. He received total gastrectomy and splenectomy 7 months before the first episode and was under chemotherapy for the gastric cancer. The first episode occurred in March 2019 and each episode had intervals of 34, 41, and 97 days, respectively. At the first and second episodes, primaquine was administered as 15 mg for 14 days. The primaquine dose was increased with 30 mg for 14 days at the third and fourth episodes. Seven gene sequences of P. vivax were analyzed and revealed totally identical for all the 4 samples. The CYP2D6 genotype was analyzed and intermediate metabolizer phenotype with decreased function was identified.

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Abstract
INTRODUCTION
CASE DESCRIPTION
DISCUSSION
REFERENCES

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