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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 146 - 146 (1page)
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Arginine methylation is a posttranslational modification mediated by protein arginine methyltransferases (PRMTs). Although previous studies have shown that PRMT1 contributes to the severity of allergic airway inflammation or asthma, the underlying mechanism is poorly understood. This study aimed to explore the role of PRMT1 and its relevant mechanism in the development of allergic rhinitis (AR). The expression levels of PRMTs and cytokines were determined by RT-PCR, and the localization of PRMT1 was determined by immunohistochemistry and confocal microscopy. The degree of mucus-producing cells and eosinophil infiltration in the mouse nasal mucosa was determined by alcian-blue periodic acid-schiff (AB/PAS) and Sirius red staining, respectively. The levels of HDM-specific immunoglobulins in mice serum and cytokines in mice nasal lavage (NAL) fluids were confirmed by enzyme-linked immunosorbent assay (ELISA). Human nasal epithelial cells were co-treated with HDM and recombinant interleukin-4 (rIL-4). PRMT1 inhibition ... 전체 초록 보기
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