In Vitro Schistosomicidal Activity of Phytol and Tegumental Alterations Induced in Juvenile and Adult Stages of Schistosoma haematobium

Maysa Ahmad Eraky; Nagwa Shaban Mohamed Aly; Rabab Fawzy Selem; Asmaa Abd El-Monem El-Kholy; Gehan Abd El-Rahman Rashed

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자료유형: 학술저널

저자정보: Maysa Ahmad Eraky (Benha University) Nagwa Shaban Mohamed Aly (Benha University) Rabab Fawzy Selem (Benha University) Asmaa Abd El-Monem El-Kholy (Benha University) Gehan Abd El-Rahman Rashed (Benha University)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.54 No.4

발행연도: 2016.8

수록면: 477 - 484 (8page)

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There is renewed interest in natural products as a starting point for discovery of drugs for schistosomiasis. Recent studies have shown that phytol reveals interesting in vivo and in vitro antischistosomal properties against Schistosoma mansoni adult worms. Here, we report the in vitro antischistosomal activity of phytol against Schistosoma haematobium juvenile and adult worms and alterations on the tegumental surface of the worms by means of scanning electron microscopy. The assay, which was carried out with 6 concentrations (25, 50, 75, 100, 125, and 150 μg/ml) of phytol, has shown a promising activity in a dose and time-dependent manner. There was a significant decline in the motility of the worms and a mortality rate of 100% was found at 48 hr after they had been exposed to phytol in the concentration of 150 μg/ml. Male worms were more susceptible. On the ultrastructural level, phytol also induced tegumental peeling, disintegration of tubercles and spines in addition to morphological disfiguring of the oral and ventral suckers. This report provides the first evidence that phytol is able to kill S. haematobium of different ages, and emphasizes that it is a promising natural product that could be used for development of a new schistosomicidal agent.

#Schistosoma haematobium #juvenile #adult #phytol #in vitro #schistosomicidal activity

참고문헌 (43)

참고문헌 신청

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[인터넷자원] - WHO / / Schistosomiasis. Fact Sheet

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