Animal Models for Echinostoma malayanum Infection : Worm Recovery and Some Pathology :Worm Recovery and Some Pathology

Jiraporn Songsri; Ratchadawan Aukkanimart; Thidarut Boonmars; Panaratana Ratanasuwan; Porntip Laummaunwai; Pranee Sriraj; Panupan Sripan

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저자정보: Jiraporn Songsri (Khon Kaen University) Ratchadawan Aukkanimart (Khon Kaen University) Thidarut Boonmars (Khon Kaen University) Panaratana Ratanasuwan (Rajamangala University of Technology Isan Sakonnakhon Campus) Porntip Laummaunwai (Khon Kaen University) Pranee Sriraj (Khon Kaen University) Panupan Sripan (Khon Kaen University)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.54 No.1

발행연도: 2016.2

수록면: 47 - 53 (7page)

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Echinostomes are intestinal trematodes that infect a wide range of vertebrate hosts, including humans, in their adult stage and also parasitize numerous invertebrate and cold-blooded vertebrate hosts in their larval stages. The purpose of this study was to compare Echinostoma malayanum parasite growth, including worm recovery, body size of adult worms, eggs per worm, eggs per gram of feces, and pathological changes in the small intestine of experimental animals. In this study, 6-8-week-old male hamsters, rats, mice, and gerbils were infected with echinostome metacercariae and then sacrificed at day 60 post-infection. The small intestine and feces of each infected animal were collected and then processed for analysis. The results showed that worm recovery, eggs per worm, and eggs per gram of feces from all infected hamsters were higher compared with infected rats and mice. However, in infected gerbils, no parasites were observed in the small intestine, and there were no parasite eggs in the feces. The volume of eggs per gram of feces and eggs per worm were related to parasite size. The results of histopathological changes in the small intestine of infected groups showed abnormal villi and goblet cells, as evidenced by short villi and an increase in the number and size of goblet cells compared with the normal control group.

#Echinostoma malayanum #echinostome #animal model #histopathology #small intestine

참고문헌 (18)

참고문헌 신청

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Tangtrongchitr A, Monzon RB. Eating habits associated with Echinostoma malayanum infections in the Philippines. Southeast Asian J Trop Med Public Health 1991; 22(suppl): 212-216.

Cho CM, Tak WY, Kweon YO, Kim SK, Choi YH, Kong HH, Chung DI. A human case of Echinostoma hortense (Trematoda: Echinostomatidae) infection diagnosed by gastroduodenal endoscopy in Korea. Korean J Parasitol 2003; 41: 117-120.

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Chai JY, Shin EH, Lee SH, Rim HJ. Foodborne intestinal flukes in Southeast Asia. Korean J Parasitol 2009; 47(suppl): S69-S102.

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